Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position.
Definition
Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. It has a role as a bronchodilator agent, a vasodilator agent, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a muscle relaxant. It is an oxopurine and a member of propane-1,2-diols.
Source: PubChem
US FDA substance register · UNII 263T0E9RR9 · registered name Dyphylline · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 479-18-5
- EC No.EU chemical inventory number
- 207-526-1
- DTXSIDUS EPA chemical ID
- DTXSID6022975
- DTXCIDUS EPA compound ID
- DTXCID102975
- IUPAC
- 7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
- Molecular formula
- C10H14N4O4
- Molecular weight
- 254.246 g/mol
Measured properties
- Appearance
- solid
- Colour
- white
- pH
- 6.6-7.3
- Melting/freezing point
- 161.5 ℃
- Initial boiling point and range
- 351 ℃
- Water solubility
- 333000 ㎎/ℓ
- Auto-ignition temperature
- 1.460 ℃
- Molecular weight
- 254.28
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Effect of intrathecal propentofylline on activation of microglias in spinal dorsal horn of rats with incisional pain · 2016
- Efficacy of 2 weeks' application of theophylline ointment in psoriasis vulgaris · 2005
- Diethylene glycol monoethyl ether (Transcutol) displays antiproliferative properties alone and in combination with xanthines. · 1996
- Dyphylline liposomes for delivery to the skin. · 1992
- The effects of dyphylline [7-(2,3-dihydroxypropyl) theophylline] on the toxicity of hycanthone on the frog's heart. · 1976
Linked databases 14
- ChEBI
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese