Ingredient Dictionary

EMODIN

Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6.

Definition

Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a laxative and a plant metabolite. It is functionally related to an emodin anthrone. It is a conjugate acid of an emodin(1-).

Source: PubChem

US FDA substance register · UNII KA46RNI6HN · registered name EMODIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

EMODININCI에모딘Korean label name (MFDS standard)

CAS No.chemical registry number: 518-82-1
EC No.EU chemical inventory number: 208-258-8
DTXSIDUS EPA chemical ID: DTXSID5025231
DTXCIDUS EPA compound ID: DTXCID205231

IUPAC: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione
Molecular formula: C15H10O5
Molecular weight: 270.24 g/mol

Measured properties

Appearance: Emodin appears as orange needles or powder. (NTP, 1992) · Solid
Odour: Orange crystals
Boiling point: Sublimes (NTP, 1992)
Melting point: 493 to 495 °F (NTP, 1992) · 256-257 °C
Solubility: less than 1 mg/mL at 66 °F (NTP, 1992) · Practically insoluble in water, soluble in alcohol, aqueous alkali hydroxide solutions (cherry red color), sodium carbonate and ammonia solutions.
Stability: This chemcial may be sensitive to prolonged exposure to light. Solns of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hr under normal lab conditions (RAD).
Melting/freezing point: 256~257 ℃
Initial boiling point and range: 529 ℃
Flash point: 288 ℃
Vapour pressure: 0.00000000001 ㎜Hg
Water solubility: 2.042 g/100㎖
n-Octanol/water partition coefficient (Kow): 4.01
Molecular weight: 270.24

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 0 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 1 studies

SkinSens1
Skin Sensitization · QSAR Predicted