Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6.
定义
Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a laxative and a plant metabolite. It is functionally related to an emodin anthrone. It is a conjugate acid of an emodin(1-).
来源: PubChem
美国FDA 物质登记 · UNII KA46RNI6HN · 登记名称 EMODIN · 单一化学物质
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 518-82-1
- EC No.欧盟化学品目录编号
- 208-258-8
- DTXSID美国EPA化学品编号
- DTXSID5025231
- DTXCID美国EPA化合物编号
- DTXCID205231
- IUPAC
- 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione
- 分子式
- C15H10O5
- 分子量
- 270.24 g/mol
实测物性
- 性状
- Emodin appears as orange needles or powder. (NTP, 1992) · Solid
- 气味
- Orange crystals
- 沸点
- Sublimes (NTP, 1992)
- 熔点
- 493 to 495 °F (NTP, 1992) · 256-257 °C
- 溶解性
- less than 1 mg/mL at 66 °F (NTP, 1992) · Practically insoluble in water, soluble in alcohol, aqueous alkali hydroxide solutions (cherry red color), sodium carbonate and ammonia solutions.
- 稳定性
- This chemcial may be sensitive to prolonged exposure to light. Solns of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hr under normal lab conditions (RAD).
- 熔点/凝固点
- 256~257 ℃
- 初沸点和沸程
- 529 ℃
- 闪点
- 288 ℃
- 蒸气压
- 0.00000000001 ㎜Hg
- 溶解度
- 2.042 g/100㎖
- 正辛醇/水分配系数（Kow）
- 4.01
- 分子量
- 270.24
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 1 项、眼部试验 0 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 1 项试验
- SkinSens1
Skin Sensitization · QSAR Predicted
来源: 美国EPA CompTox
相关文献
- Emodin and Aloe-Emodin Reduce Cell Growth and Disrupt Metabolic Plasticity in Human Melanoma Cells · 2025
- Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance · 2023
- The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy · 2022
- Poloxamer-Based Thermoreversible Gel for Topical Delivery of Emodin: Influence of P407 and P188 on Solubility of Emodin and Its Application in Cellular Activity Screening · 2017
- In vitro and in vivo antileishmanial effects of aloe-emodin on Leishmania major · 2015