Esculin is a hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin.
Definition
US FDA substance register · UNII 1Y1L18LQAF · registered name ESCULIN · single chemical substance
Esculin is a hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin. It has a role as an antioxidant and a metabolite. It is a beta-D-glucoside and a hydroxycoumarin. It is functionally related to an esculetin.
Source: PubChem
Esculin is a glucoside compound originally obtained from the leaves and bark of the horse chestnut tree, Aesculus hippocastanum. It conforms to the formula
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name エスクリン: 本品は、セイヨウトチノキ Aesculus hippocastanum の葉と樹皮から得られる配糖体であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 531-75-9
- EC No.EU chemical inventory number
- 208-517-5
- DTXSIDUS EPA chemical ID
- DTXSID7045318
- DTXCIDUS EPA compound ID
- DTXCID5025318
- IUPAC
- 7-Hydroxy-2-oxo-2H-1-benzopyran-6-yl beta-D-glucopyranoside
- Molecular formula
- C15H16O9
- Molecular weight
- 340.284 g/mol
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Humectant3
- Stabilizing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Esculin improves wound healing in diabetic rats by modulating extracellular matrix remodeling and molecular pathways · 2026
- Laccase-Catalyzed Oligomerization of Esculin: Effect of Key Reaction Parameters and Evaluation of Oligoesculin Antioxidant and Skin Prebiotic Capacity · 2025
- Esculin promotes skin wound healing in mice and regulates the Wnt/β-catenin signaling pathway · 2025
- A novel esculin-loaded bacterial nanocellulose wound dressing enhances cutaneous wound healing via modulation of inflammation, oxidative stress, and growth factor expression. · 2025
- Esculin and ferric citrate-incorporated sturgeon skin gelatine as an antioxidant film for food packaging to prevent Enterococcus faecalis contamination. · 2020
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese