Ingredient Dictionary

ESTRADIOL

17beta-estradiol is the 17beta-isomer of estradiol.

Definition

17beta-estradiol is the 17beta-isomer of estradiol. It has a role as a geroprotector, an estrogen, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a mouse metabolite, a human metabolite and a Daphnia magna metabolite. It is an estradiol and a 17beta-hydroxy steroid.

Source: PubChem

US FDA substance register · UNII 4TI98Z838E · registered name Estradiol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Banned: Canada · Taiwan
Restricted or banned: Argentina · ASEAN · Brazil · Canada · China · European Union · Japan · South Korea · Taiwan

Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/260

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name エストラジオール: 本品は、卵胞ホルモンであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

ESTRADIOLINCI에스트라다이올Korean label name (MFDS standard)エストラジオールJapanese labelling name

CAS No.chemical registry number: 50-28-2
EC No.EU chemical inventory number: 200-023-8
DTXSIDUS EPA chemical ID: DTXSID0020573
DTXCIDUS EPA compound ID: DTXCID80573

IUPAC: Estra-1(10),2,4-triene-3,17beta-diol
Molecular formula: C18H24O2
Molecular weight: 272.388 g/mol

Measured properties

Appearance: Solid · White powder.
Odour: Odorless
Boiling point: 445.9±45.0
Melting point: 173 · 178.5 °C
Solubility: 3.6 mg/L (at 27 °C) · Very soluble in acetone, ethanol, dioxane
Dissociation constant: 10.46±0.03
Melting/freezing point: 178.5 ℃
Vapour pressure: 0.0000000126 ㎜Hg
Water solubility: 3.6 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 4.01
Molecular weight: 272.39

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 0 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 1 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)