Ingredient Dictionary

ETHOXYDIGLYCOL

Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2.

How much products actually contain

No product states its amount yet.

Of the products containing it, 72 list it before the 1% line and 62 after it (usually 1% or less).

Products using this ingredient

12 of 134 confirmed · likeliest to carry enough first · See all 134

Definition

Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a primary alcohol, a glycol ether, a diether and a hydroxypolyether. It is functionally related to a diethylene glycol.

Source: PubChem

US FDA substance register · UNII A1A1I8X02B · registered name Diethylene glycol monoethyl ether · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENTDraws in and holds moistureHUMECTANTGives the product a scentPERFUMING

Safety & regulatory references

Restricted: Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : (a) Oxidative hair dye products (b) Non-oxidative hair dye products (c) Rinse-off products other than hair dye products (d) Other non-spray cosmetic products (e) The following spray products: fine fragrances, hairsprays, anti-perspirants and deodorant
Maximum authorised concentration in the finished cosmetic product : (a) 7% (b) 5% (c) 10% (d) 2.6% (e) 2.6%
Other limitations and requirements : (a) to (e): The level of ethylene glycol impurity in Ethoxydiglycol must be ≤0.1% Not to be used in eye products and oral products

European Union

Product Type, body parts : (a) Oxidative hair day products (b) Non-oxidative hair dye products (c) Rinse-off products other than hair dye products (d) Other non-spray cosmetic products (e) The following spray products: fine fragrances, hair sprays, antiperspirant and deodorant
Maximum concentration in ready for use preparation : (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6%
Other : (a) to (e): The level of ethylene glycol impurity in Ethoxydiglycol must be ≤ 0,1 %. Not to be used in eye products and oral products

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 297 · maximum concentration (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6% · applies to (a) Oxidative hair day products (b) Non-oxidative hair dye products (c) Rinse-off products other than hair dye products (d) Other non-spray cosmetic products (e) The following spray products: fine fragrances, hair sprays, antiperspirant and deodorant

Source: EU restricted substances (Annex III)

Restriction III/297 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Diethylene Glycol Monoethyl Ether (DEGEE)

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name エトキシジグリコール: 本品は、次の化学式で表されるエーテルアルコールである。

Source: JCIA labelling names (Japan)

Names & identifiers

ETHOXYDIGLYCOLINCI에톡시다이글라이콜Korean label name (MFDS standard)Ethanol, 2-(2-ethoxyethoxy)-SynonymエトキシジグリコールJapanese labelling name

CAS No.chemical registry number: 111-90-0
EC No.EU chemical inventory number: 203-919-7
DTXSIDUS EPA chemical ID: DTXSID2021941
DTXCIDUS EPA compound ID: DTXCID501941

IUPAC: 2-(2-Ethoxyethoxy)ethan-1-ol
Molecular formula: C6H14O3
Molecular weight: 134.175 g/mol

Measured properties

Appearance: Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190 °F. Used to make soaps, dyes, and other chemicals. · Liquid, CBI, Other Solid
Odour: Mild, pleasant odor
Boiling point: 396 °F at 760 mmHg (NTP, 1992) · boiling point equals 396 °F
Melting point: -108 °F (NTP, 1992) · Freezing point = -54.0 °C
Solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) · Miscible with ether, pyridine, chloroform
Density: 0.99 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.9885 g/cu cm at 20 °C
Viscosity: 3.85 mPa.s (=cPs) at 25 °C · 3.83 cP (25 C)
Colour: colourless
Odour threshold: 1.10 ppm
Melting/freezing point: -76 ℃
Initial boiling point and range: 196~202 ℃
Flash point: 96 ℃((o.c.))
Upper/lower flammability or explosive limits: 1.2 / 23.5 %
Vapour pressure: 0.126 ㎜Hg ( (25 ℃))
Vapour density: 4.64
Relative density: 0.9902 ( (20 ℃))
n-Octanol/water partition coefficient (Kow): -0.54
Auto-ignition temperature: 204 ℃
Molecular weight: 134.20

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 191 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance95
Solvent37
Wetting agent (non-aqueous)20
Solubility enhancer16
Adhesion/cohesion promoter6
Humectant5
Intermediate2
Film former2

8 other uses

Processing aids not otherwise specified1
Stabilizing agent1
Astringent (EPA)1
Degradant/impurity (EPA)1
Emulsifier1
Anti-freeze agent1
Surfactant (surface active agent)1
Viscosity modifier1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 5 eye studies are on record.

Classed as moderate1Classed as low1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Category 6.3B (Category 3)
Skin Irritation · Read Across
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Ambiguous
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to no guideline followed
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to