Ethylene Glycol Monoethyl Ether can cause developmental toxicity and male reproductive toxicity according to an independent committee of scientific and health experts.
Definition
Ethylene Glycol Monoethyl Ether can cause developmental toxicity and male reproductive toxicity according to an independent committee of scientific and health experts.
Source: PubChem
US FDA substance register · UNII IDK7C2HS09 · registered name ETHYLENE GLYCOL MONOETHYL ETHER · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · International fragrance standard (IFRA) · South Korea · Taiwan
Source: ASEAN Cosmetic Directive · Health Canada Cosmetic Ingredient Hotlist · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H302 (category 4) · H360 (category 1B) · H226 (category 3) · +1 more
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/666
Source: EU CosIng ingredient list
Reviewed by CIR: Special Report on the Reproductive and Developmental Toxicity of Ethylene Glycol and its Ethers
Reviewed by CIR: Final Report on the Safety Assessment of Ethoxyethanol and Ethoxyethanol Acetate
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name エトキシエタノール: 本品は、次の化学式で表されるエーテルアルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 110-80-5
- EC No.EU chemical inventory number
- 203-804-1
- DTXSIDUS EPA chemical ID
- DTXSID7024087
- DTXCIDUS EPA compound ID
- DTXCID604087
- IUPAC
- 2-Ethoxyethan-1-ol
- Molecular formula
- C4H10O2
- Molecular weight
- 90.122 g/mol
Measured properties
- Appearance
- liquid
- Melting/freezing point
- -70 ℃
- Initial boiling point and range
- 135 ℃
- Flash point
- 40 ℃((1,013hPa))
- Upper/lower flammability or explosive limits
- 15.6 / 1.7 %
- Vapour pressure
- 5.31 ㎜Hg(25℃)
- Water solubility
- 1000000 ㎎/ℓ
- Vapour density
- 3.1
- Relative density
- 0.929 (25℃)
- n-Octanol/water partition coefficient (Kow)
- -0.32
- Auto-ignition temperature
- 235 ℃
- Viscosity
- 1.84 cP(25℃)
- Molecular weight
- 90.12
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 21 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent10
- No specific technical function5
- Processing aids not otherwise specified2
- Fragrance1
- Monomers1
- Intermediate1
- Viscosity modifier1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: EEC Directive 83/467/EEC according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not classified
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Category 6.3B (Category 3)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Directive annex: 92/69/EEC: July 1992 according to - Category 2B
Eye Irritation · Screening - Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Range measurement and fluorescence imaging analysis using electron beams with new liquid scintillator based on alcohol. · 2021
- Determination of Four Forbidden Substances Including 2-Methoxyethanol in Cosmetics by GC and GC/MS · 2012
- Final Report on the Safety Assessment of Ethoxyethanol and Ethoxyethanol Acetate · 2002
- Percutaneous penetration and metabolism of 2-ethoxyethanol. · 2002
- Derivatization Procedure and HPLC Determination of 2‐Ethoxyethanol in Cosmetic Samples · 1999
Linked databases 22
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese