Ingredient Dictionary

ETHYL 3,4-DIHYDROXYBENZOATE

Ethyl 3,4-dihydroxybenzoate is an ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol.

Definition

Ethyl 3,4-dihydroxybenzoate is an ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa. It has a role as an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor, an antioxidant, an antibacterial agent, an apoptosis inducer and a plant metabolite. It is an ethyl ester and a member of catechols. It is functionally related to a 3,4-dihydroxybenzoic acid.

Source: PubChem

US FDA substance register · UNII 4YGJ96WTBG · registered name ETHYL PROTOCATECHUATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Ethyl 3,4-Dihydroxybenzoate is the ethyl ester of 3,4-Dihydroxybenzoic Acid that conforms to the formula

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANTInhibits microbial growthANTIMICROBIALSkin conditioning not covered aboveSKIN CONDITIONING - MISCELLANEOUS

More data — names, identifiers, properties, test records, literature

Names & identifiers

ETHYL 3,4-DIHYDROXYBENZOATEINCI

CAS No.chemical registry number: 3943-89-3
EC No.EU chemical inventory number: 223-529-0
DTXSIDUS EPA chemical ID: DTXSID2057732
DTXCIDUS EPA compound ID: DTXCID3031521

IUPAC: Ethyl 3,4-dihydroxybenzoate
Molecular formula: C9H10O4
Molecular weight: 182.175 g/mol

Measured properties

Appearance: solid
Melting/freezing point: 44 ℃
Initial boiling point and range: 441.82 ℃
Vapour pressure: 0 ㎩ (20°C)
Water solubility: (&amp, lt, 20 μg @ 20°C)
Vapour density: 14.17777010700725
Relative density: 0.917 (g/cm³ at 20°C)
Molecular weight: 410.73

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

Irritation and sensitisation studies

2 skin studies and 0 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

SkinSens1
Skin Sensitization · QSAR Predicted
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)

Source: US EPA CompTox dashboard