Ingredient Dictionary

ETHYL ACETATE

Ethyl acetate is the acetate ester formed between acetic acid and ethanol.

How much products actually contain

No product states its amount yet.

Of the products containing it, 2,006 list it before the 1% line and 7 after it (usually 1% or less).

Products using this ingredient

12 of 2,012 confirmed · likeliest to carry enough first · See all 2,012

Definition

Ethyl acetate is the acetate ester formed between acetic acid and ethanol. It has a role as a metabolite, a polar aprotic solvent, a Saccharomyces cerevisiae metabolite and an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor. It is a volatile organic compound, an ethyl ester and an acetate ester.

Source: PubChem

US FDA substance register · UNII 76845O8NMZ · registered name Ethyl acetate · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMINGBase that dissolves other ingredientsSOLVENT

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H319 (category 2) · H225 (category 2) · H336 (category 3)

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Ethyl Acetate and Butyl Acetate

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 酢酸エチル: 本品は、酢酸（＊）のエチルエステルであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

ETHYL ACETATEINCI에틸아세테이트Korean label name (MFDS standard)Acetic acid, ethyl esterSynonym酢酸エチルJapanese labelling name

CAS No.chemical registry number: 141-78-6
EC No.EU chemical inventory number: 205-500-4
DTXSIDUS EPA chemical ID: DTXSID1022001
DTXCIDUS EPA compound ID: DTXCID602001

IUPAC: Ethyl acetate
Molecular formula: C4H8O2
Molecular weight: 88.106 g/mol

Measured properties

Appearance: Ethyl acetate appears as a clear colorless liquid with a fruity odor. Flash point 24 °F. Less dense than water. Vapors heavier than air. · Liquid, CBI, Other Solid
Odour: CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE. · Fragrant odor
Boiling point: 171 °F at 760 mmHg (NTP, 1992) · 77.1 °C
Melting point: -118.5 °F (NTP, 1992) · -83.8 °C
Solubility: 50 to 100 mg/mL at 70 °F (NTP, 1992) · In water, 8.0X10+4 mg/L at 25 °C
Colour: colourless
Odour threshold: 3.9 ppm
Melting/freezing point: -84 ℃
Initial boiling point and range: 77 ℃
Flash point: -4 ℃
Upper/lower flammability or explosive limits: 11.5 / 2.2 %
Vapour pressure: 93.2 ㎜Hg(25℃)
Water solubility: 6.4 g/100㎖(25 ℃)
Vapour density: 3.0
Relative density: 0.9
n-Octanol/water partition coefficient (Kow): 0.73
Auto-ignition temperature: 427 ℃
Viscosity: 0.44 cP(25℃)
Molecular weight: 88.11

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 119 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance47
Solvent40
Flavouring and nutrient6
Adhesion/cohesion promoter6
Processing aids not otherwise specified3
Pigment3
Intermediate3
Binder2

8 other uses

Anti-adhesive/cohesive2
Defoamer1
Dispersing agent1
Dye1
Cleaning agent1
Diluent1
Filler1
Sealant (barrier)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 6 eye studies are on record.

Classed as moderate2Classed as low5

The studies disagree (the most common conclusion covers 29%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 12 studies

Not classified
Skin Irritation · Screening
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not classified
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: "Classification of Corrosive Hazards", Federal Reg vol 37, 57 (1972) according to other guideline: US Code of Federal Regulations 1500.41 (2009) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Category 2B
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Screening
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Eye Irrit. 2
Eye Irritation · Authoritative