Ingredient Dictionary

ETHYL ACETOACETATE

Ethyl acetoacetate is an ethyl ester resulting from the formal condensation of the carboxy group of acetoacetic acid with ethanol.

Definition

Ethyl acetoacetate is an ethyl ester resulting from the formal condensation of the carboxy group of acetoacetic acid with ethanol. It has a role as an antibacterial agent, a flavouring agent and a plant metabolite. It is functionally related to an acetoacetic acid.

Source: PubChem

US FDA substance register · UNII IZP61H3TB1 · registered name Ethyl acetoacetate · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アセト酢酸エチル: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

ETHYL ACETOACETATEINCI에틸아세토아세테이트Korean label name (MFDS standard)Butanoic acid, 3-oxo-, ethyl esterSynonymアセト酢酸エチルJapanese labelling name

CAS No.chemical registry number: 141-97-9
EC No.EU chemical inventory number: 205-516-1
DTXSIDUS EPA chemical ID: DTXSID2027092
DTXCIDUS EPA compound ID: DTXCID207092

IUPAC: Ethyl 3-oxobutanoate
Molecular formula: C6H10O3
Molecular weight: 130.143 g/mol

Measured properties

Appearance: Ethyl acetoacetate appears as a colorless liquid with a fruity odor. Flash point 185 °F. Boiling point 365 °F. May cause adverse health effects if ingested or inhaled. May irritate to skin, eyes and mucous membranes. Used in organic synthesis and in lacquers and paints. · Dry Powder, Liquid
Odour: PLEASANT GREEN, FRUITY, RUM ODOR
Boiling point: 363 °F at 760 mmHg (USCG, 1999) · 180.8 °C AT 760 MM HG
Melting point: less than -112 °F (USCG, 1999) · -45 °C
Solubility: SOL IN ABOUT 35 PARTS WATER · SOL IN BENZENE, & CHLOROFORM, MISCIBLE WITH ETHER, & ACETONE
Density: 1.028 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.0282 AT 20 °C/4 °C
Colour: colourless
Melting/freezing point: -45 ℃
Initial boiling point and range: 181 ℃
Flash point: 70 ℃
Upper/lower flammability or explosive limits: 54.0 / 1.0 %
Vapour pressure: 0.78 ㎜Hg (at 25C)
Water solubility: 110000 ㎎/ℓ (at 17C)
Vapour density: 4.48 ()
Relative density: 1.0250 ()
n-Octanol/water partition coefficient (Kow): 0.25
Auto-ignition temperature: 295 ℃
Molecular weight: 130.1

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 93 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance85
Solvent3
Flavouring and nutrient3
Intermediate2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: DOT (Transport-Classification) Guideliens according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) of 12 May 1981 (Footpad method)
Classification not possible
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
Category 2B
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across