Ingredient Dictionary

ETHYL ISOBUTYRATE

Ethyl isobutyrate is a fatty acid ethyl ester obtained by the formal condensation of isobutyric acid with ethanol.

Definition

Ethyl isobutyrate is a fatty acid ethyl ester obtained by the formal condensation of isobutyric acid with ethanol. It has a role as a plant metabolite. It is functionally related to an isobutyric acid.

Source: PubChem

US FDA substance register · UNII 9A9661LN4H · registered name Ethyl isobutyrate · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

ETHYL ISOBUTYRATEINCIPropanoic acid, 2-methyl-, ethyl esterSynonym

CAS No.chemical registry number: 97-62-1
EC No.EU chemical inventory number: 202-595-4
DTXSIDUS EPA chemical ID: DTXSID7047728
DTXCIDUS EPA compound ID: DTXCID6027717

IUPAC: Ethyl 2-methylpropanoate
Molecular formula: C6H12O2
Molecular weight: 116.16 g/mol

Measured properties

Appearance: liquid
Colour: colourless
Melting/freezing point: -88 ℃
Initial boiling point and range: 110.1 ℃
Flash point: 13 ℃(c.c.)
Upper/lower flammability or explosive limits: 7.8 / 1.3 %
Vapour pressure: 26 ㎜Hg
Water solubility: 3170 ㎎/ℓ (25℃(est.))
Vapour density: 4
Relative density: 0.8904
n-Octanol/water partition coefficient (Kow): 1.77 (est.)
Auto-ignition temperature: 463 ℃
Molecular weight: 116.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 25 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance23
Flavouring and nutrient2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 3 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Classification not possible
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Classification not possible
Skin Sensitization · Screening
Classification not possible
Eye Irritation · Screening
Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to