Ethyl 2-hydroxypropanoate is the ethyl ester obtained of 2-hydroxypropanoic acid.
Definition
Ethyl 2-hydroxypropanoate is the ethyl ester obtained of 2-hydroxypropanoic acid. It has a role as a metabolite. It is an ethyl ester, a secondary alcohol and a lactate ester. It is functionally related to a 2-hydroxypropanoic acid.
Source: PubChem
US FDA substance register · UNII F3P750VW8I · registered name Ethyl lactate · single chemical substance
Cosmetic roles
Safety & regulatory references
Taiwan
- Maximum concentration : pH≧3.5;
- pH≥3.5;
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
Reviewed by CIR: Final Report on the Safety Assessment of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, and Lactic Acid, Ammonium, Calcium, Potassium, Sodium, and TEA-Lactates, Methyl, Ethyl, Isopropyl, and Butyl Lactates, and Lauryl, Myristyl, and Cetyl Lactates
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name 乳酸エチル: 本品は、乳酸(*)とエタノール(*)とのエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 97-64-3
- EC No.EU chemical inventory number
- 202-598-0
- DTXSIDUS EPA chemical ID
- DTXSID6029127
- DTXCIDUS EPA compound ID
- DTXCID509127
- IUPAC
- Ethyl 2-hydroxypropanoate
- Molecular formula
- C5H10O3
- Molecular weight
- 118.132 g/mol
Measured properties
- Appearance
- Ethyl lactate appears as a clear colorless liquid with a mild odor. Flash point 115 °F. Denser than water and soluble in water. Vapors heavier than air. · CBI, Liquid
- Odour
- Buttery odor · Fruity butterscotch
- Boiling point
- 309 °F at 760 mmHg (USCG, 1999) · 154 °C
- Melting point
- -26 °C · -26.00 °C. @ 760.00 mm Hg
- Solubility
- Miscible with water · Miscible with alcohol, ketones, esters, hydrocarbons, oil
- Density
- 1.03 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.0328 g.cu cm at 20 °C
- Colour
- colourless
- Odour threshold
- 14 ppm
- Melting/freezing point
- -25 ℃
- Initial boiling point and range
- 154 ℃
- Flash point
- 46.1 ℃
- Upper/lower flammability or explosive limits
- 14.1 / 1.5 %
- Vapour pressure
- 3.75 ㎜Hg (at 25℃)
- Water solubility
- 1000000 ㎎/ℓ (at 20℃)
- Vapour density
- 4.07
- Relative density
- 1.0328 (at 20℃)
- n-Octanol/water partition coefficient (Kow)
- -0.18
- Auto-ignition temperature
- 400 ℃
- Molecular weight
- 118.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 32 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent11
- Fragrance8
- Flavouring and nutrient5
- Pharmaceutical (EPA)3
- Surfactant (surface active agent)2
- Cleaning agent1
- Processing aids not otherwise specified1
- Diluent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Classification not possible
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening - Category 2
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Extraction of Polyphenols and Vitamins Using Biodegradable ATPS Based on Ethyl Lactate · 2022
- RIFM fragrance ingredient safety assessment, ethyl lactate, CAS Registry Number 97-64-3. · 2020
- Evaluation of topical antifungal products in an in vitro onychomycosis model · 2016
- Residual antibacterial activity of dog hairs after therapy with antimicrobial shampoos. · 2013
- Effects of an ethyl lactate shampoo in conjunction with a systemic antibiotic in the treatment of canine superficial bacterial pyoderma in an open-label, nonplacebo-controlled study. · 2003
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese