Ethyl vanillin is a member of the class of benzaldehydes that is vanillin in which the methoxy group is replaced by an ethoxy group.
How much products actually contain
No product states its amount yet.
Of the products containing it, 41 list it before the 1% line and 13 after it (usually 1% or less).
Products using this ingredient
12 of 54 confirmed · likeliest to carry enough first · See all 54
FOELLIEInner Perfume Eau de Bijou
ColourPopColourPop Immortal Kiss
ColourPopColourPop Just Bitten
ColourPopColourPop New Love
ColourPopColourPop Opposites Attract
r.e.m. beautyr.e.m. beauty classic lipstick
r.e.m. beautyr.e.m. beauty dangerous woman lip mask
r.e.m. beautyr.e.m. beauty glossy balm
Tower 28Tower 28 ShineOn Plumping Lip Jelly
ColourPopColourPop Primer
r.e.m. beautyr.e.m. beauty matte lipstick
ColourPopColourPop Cookie
Definition
Ethyl vanillin is a member of the class of benzaldehydes that is vanillin in which the methoxy group is replaced by an ethoxy group. It has a role as an antioxidant and a flavouring agent. It is a member of benzaldehydes, a member of phenols and an aromatic ether. It is functionally related to a vanillin.
Source: PubChem
US FDA substance register · UNII YC9ST449YJ · registered name ETHYL VANILLIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name エチルバニリン: 本品は、次の化学式で表されるフェノール誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 121-32-4
- EC No.EU chemical inventory number
- 204-464-7
- DTXSIDUS EPA chemical ID
- DTXSID5021968
- DTXCIDUS EPA compound ID
- DTXCID901968
- IUPAC
- 3-Ethoxy-4-hydroxybenzaldehyde
- Molecular formula
- C9H10O3
- Molecular weight
- 166.176 g/mol
Measured properties
- Appearance
- Ethyl vanillin appears as colorless crystals. More intense vanilla odor and taste than vanillin. (NTP, 1992) · Large Crystals, CBI, Other Solid, Dry Powder, Liquid
- Odour
- Finer and more intense vanilla · Resembles that of vanillin but approximately 3 times as strong.
- Boiling point
- 285 °C · 285.00 to 294.00 °C. @ 760.00 mm Hg
- Melting point
- 171 to 172 °F (NTP, 1992) · 76.7 °C
- Solubility
- Slightly soluble (NTP, 1992) · In water, 2,822 mg/L at 25 °C
- Stability
- NOT STABLE, IN CONTACT WITH IRON OR ALKALI, IT EXHIBITS A RED COLOR & LOSES ITS FLAVORING POWER · AFFECTED BY LIGHT
- pH
- Solutions are acid to litmus
- Melting/freezing point
- 77.5 ℃
- Initial boiling point and range
- 294 ℃
- Flash point
- 145 ℃(c.c.)
- Vapour pressure
- 0.0000104 ㎜Hg (@ 25 ℃)
- Water solubility
- 2820 ㎎/ℓ (@ 25 ℃)
- Vapour density
- 5.74
- Relative density
- 1.307 (@ 20.6 ℃)
- n-Octanol/water partition coefficient (Kow)
- 1.58
- Auto-ignition temperature
- 400 ℃
- Molecular weight
- 166.18
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 412 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance385
- Flavouring and nutrient19
- Deodorizer4
- Humectant2
- Processing aids not otherwise specified1
- pH regulating agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: in-vitro Eye irritation test: Human corneal model test according to - Serious eye damage/eye irritation - Category 2B
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- A heat-controlled release system of ethyl vanillin based on acyclic cucurbit[n]urils · 2022
- E-Cigarette Fluids and Aerosol Residues Cause Oxidative Stress and an Inflammatory Response in Human Keratinocytes and 3D Skin Models · 2021
- Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems · 2021
- Vanillin and Vanillin Analogs Relax Porcine Coronary and Basilar Arteries by Inhibiting L-Type Ca2+ Channels · 2015
- A Vanillin Derivative Causes Mitochondrial Dysfunction and Triggers Oxidative Stress in Cryptococcus neoformans · 2014
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese