Definition
US FDA substance register · UNII 56IT408V5Y · registered name Diethoxymethane · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 462-95-3
- EC No.EU chemical inventory number
- 207-330-6
- DTXSIDUS EPA chemical ID
- DTXSID6052112
- DTXCIDUS EPA compound ID
- DTXCID8030681
- IUPAC
- (Ethoxymethoxy)ethane
- Molecular formula
- C5H12O2
- Molecular weight
- 104.149 g/mol
Measured properties
- Appearance
- liquid
- Melting/freezing point
- -66.5 ℃
- Initial boiling point and range
- 88 ℃
- Flash point
- -5 ℃
- Vapour pressure
- 34.1 ㎜Hg (25℃)
- Water solubility
- 70000 ㎎/ℓ (18℃)
- Relative density
- 0.8319 (20℃)
- n-Octanol/water partition coefficient (Kow)
- 0.84
- Molecular weight
- 104.148
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent3
- Intermediate1
- Flavouring and nutrient1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: internal SOP TA 320 and TA 160 according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: internal SOP TA 180 - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: Internal SOP TA 330 and TA 150 according to
Source: US EPA CompTox dashboard
Related literature
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- Tlooto literature search
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Chinese