Definition
US FDA substance register · UNII R63ZWW1A13 · registered name 2-ETHYLHEXYL BENZOATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Alkyl Benzoates as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name 安息香酸エチルヘキシル: 本品は、安息香酸（＊）と２－エチルヘキシルアルコールとのエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5444-75-7
- EC No.EU chemical inventory number
- 226-641-8
- DTXSIDUS EPA chemical ID
- DTXSID4041654
- DTXCIDUS EPA compound ID
- DTXCID2021654
- IUPAC
- 2-Ethylhexyl benzoate
- Molecular formula
- C15H22O2
- Molecular weight
- 234.339 g/mol
Measured properties
- Appearance
- Liquid · Colourless clear oily liquid, Ethereal aroma
- Boiling point
- 120-121 °C (3 mm Hg)
- Solubility
- Practically insoluble or insoluble in water · Soluble (in ethanol)
- Density
- 0.963-0.973 (20 °C)
- Melting/freezing point
- -98 ℃
- Initial boiling point and range
- 303 ℃
- Flash point
- 159 ℃
- Vapour pressure
- 0.037 ㎪
- Water solubility
- 0.4 ㎎/ℓ
- Relative density
- 0.968 g/cm³
- n-Octanol/water partition coefficient (Kow)
- 6.21
- Auto-ignition temperature
- 374 ℃
- Viscosity
- (6.22 mm²/s (static)(25℃))
- Molecular weight
- 234.334
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 15 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner5
- Surfactant (surface active agent)3
- Solvent2
- Flavouring and nutrient1
- Diluent1
- Film former1
- Wetting agent (non-aqueous)1
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) according to EPA OPPTS 870.2600 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
Linked databases 18
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata