Definition
US FDA substance register · UNII 8Q7XLQ325N · registered name 2-ETHYLHEXYL METHACRYLATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name メタクリル酸エチルヘキシル: 本品は、メタクリル酸と２－エチルヘキサノールのエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 688-84-6
- DTXSIDUS EPA chemical ID
- DTXSID3027293
- DTXCIDUS EPA compound ID
- DTXCID007293
- IUPAC
- 2-Ethylhexyl 2-methylprop-2-enoate
- Molecular formula
- C12H22O2
- Molecular weight
- 198.306 g/mol
Measured properties
- Appearance
- Liquid, CBI · Liquid, [ICSC] Colorless liquid with an odor of ether, [MSDSonline]
- Boiling point
- 110 °C @ 14 mm Hg · 113-224 °C
- Solubility
- Solubility in water: none
- Density
- 0.880 g/cu cm @ 25 °C · Relative density (water = 1): 0.9
- Stability
- Storage of this product at elevated temperatures (>30 °C or >85 °F) reduces the shelf-life. The typical shelf-life for this product is 12 months. /Formulation >99% 2-ethylhexyl methacrylate/
- Initial boiling point and range
- 113~224 ℃
- Flash point
- 92 ℃
- Vapour pressure
- 133 ㎩ (20℃)
- Water solubility
- 0.000592 g/100㎖ (25℃ (est.))
- Vapour density
- 6.8
- Relative density
- 0.9
- n-Octanol/water partition coefficient (Kow)
- 4.54
- Molecular weight
- 198.3
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Monomers2
- Surfactant (surface active agent)2
- Film former1
- Cleaning agent1
- Processing aids not otherwise specified1
- Intermediate1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 20%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: Federal Hazardous Substances Labeling Act Regulations, Section 191.12, Federal Register: 29, 13009 (1964) according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) individual approach (adopted 22 July 2010) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) (dated May 30, 2008) - Category 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: "Appraisal of the safety of chemicals in foods, drugs and cosmetics", Division of Pharmacology, FDA (Draize) (1959). according to - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Not classified
Eye Irritation · Screening - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: Federal Hazardous Substances Labeling Act Regulations, Section 191.12, Federal Register: 29, 13009 (1964) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: "Appraisal of the safety of chemicals in foods, drugs and cosmetics", Division of Pharmacology, FDA (Draize) (1959) according to
Source: US EPA CompTox dashboard
Related literature
- Biofluorometric Ear-Gas Sensing for Non-Invasive Monitoring of Blood EtOH · 2024
- Assessment of the skin sensitising potency of the lower alkyl methacrylate esters. · 2014
- Influence of the bulk and surface morphology on adhesion of polystyrene‐inter‐poly‐cross‐2‐ethylhexyl‐methacrylate films and particles · 1996
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata