Ingredient Dictionary

FOLIC ACID

Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9.

How much products actually contain

53 products state the amountmedian 0.0000048%

under 0.01% 53
0.01–0.1% 0
0.1–1% 0
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 50 list it before the 1% line and 263 after it (usually 1% or less).

Products using this ingredient

12 of 312 confirmed · likeliest to carry enough first · See all 312

Definition

Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a nutrient, a mouse metabolite and a human metabolite. It is a member of folic acids and a N-acyl-amino acid. It is functionally related to a pteroic acid. It is a conjugate acid of a folate(2-).

Source: PubChem

US FDA substance register · UNII 935E97BOY8 · registered name Folic acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 葉酸: 本品は、グルタミン酸誘導体であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

FOLIC ACIDINCI폴릭애씨드Korean label name (MFDS standard)L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-Synonym葉酸Japanese labelling name

CAS No.chemical registry number: 59-30-3
EC No.EU chemical inventory number: 200-419-0
DTXSIDUS EPA chemical ID: DTXSID0022519
DTXCIDUS EPA compound ID: DTXCID102519

IUPAC: N-(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
Molecular formula: C19H19N7O6
Molecular weight: 441.404 g/mol

Measured properties

Appearance: Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482 °F. · Yellowish-orange solid, [Merck Index] Yellow solid, [Sigma-Aldrich MSDS]
Odour: Odorless or almost odorless · odourless
Melting point: 482 °F (decomposes) (NTP, 1992) · 250 °C
Solubility: Almost insoluble (NTP, 1992) · Slightly sol in methanol, less in ethanol and butanol, insol in acetone, chloroform, ether, benzene, relatively sol in acetic acid, phenol, pyridine, and in soln of alkali hydroxides and carbonates. Soluble in hot dil HCl and H2SO4.
Stability: Aqueous solutions of folic acid are heat sensitive and decompose rapidly in the presence of light and /or riboflavin, solutions should be protected from light. · Inactivated by light with formation of xanthopterinaldehyde, crystalline is stable at 4 °C.
pH: A suspension of 1 g of folic acid in 10 ml of water has a pH of 4.0-4.8. Aq solutions prepared with sodium bicarbonate have a pH between 6.5 and 6.8. · 4~4.8
Dissociation constant: pKa = 3.5, 4.3 (carboxylic acid moieties) /Estimated/
Vapour pressure: (3.37x10-21 mmHg @ 25 ℃, est.)
Water solubility: 1.6 ㎎/ℓ (Water Solubility 25 ℃)
Vapour density: 15.24
n-Octanol/water partition coefficient (Kow): -2.81 (est.)
Decomposition temperature: 250 ℃
Molecular weight: 441.40

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner3
Flavouring and nutrient2

Source: US EPA CompTox dashboard