Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9.
产品中实际含有多少
标示含量的产品 53 款中位数 0.0000048%
- 低于 0.01% 53
- 0.01–0.1% 0
- 0.1–1% 0
- 1% 以上 0
标示含量的多为以该成分命名的产品，数值可能偏向象征性的少量添加。
含该成分的产品中，50 款将其列在 1% 线之前，263 款列在之后（通常不超过 1%）。
含有此成分的产品
已确认 312 款中的 12 款 · 按含量充足程度排序 · 查看全部 312 款
Biome ActivateSuper Crema Multi Vita Cream标示 0.0001%
MIPVita Energy Cleansing Foam标示 0.00001%
BanobagiVita Genic Jelly Mask (10 Sheets), 7 Types标示 0.00001%
MEDIPEELMEDIPEEL Vegan Vitamin Deep-Tox Cleansing Oil标示 0.000001%
MEDIPEELMEDIPEEL [Makeup Deep Cleansing] Vegan Vitamin Deep-Tox Cleansing Oil 200ml标示 0.000001%
REPLYMEZanmang Loopy Biocellulose Vitamin Facial Fit Mask Pack标示 0.0000004%
ENOUGHReal Vita 8 Complex Pro Brighten-Up Ampoule标示 0.00000005%
ENOUGHReal Vita 8 Essence标示 0.00000005%
ENOUGHReal Vita 8 Eye Cream标示 0.00000005%
MEDIPEELMEDIPEEL Algo-Tox Vita Cleanser 150ml标示 0.00000001%
TENZEROTENZERO Brightening Vitamin Body Wash
TENZEROTENZERO Brightening Vitamin Body Lotion
定义
Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a nutrient, a mouse metabolite and a human metabolite. It is a member of folic acids and a N-acyl-amino acid. It is functionally related to a pteroic acid. It is a conjugate acid of a folate(2-).
来源: PubChem
美国FDA 物质登记 · UNII 935E97BOY8 · 登记名称 Folic acid · 单一化学物质
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 葉酸: 本品は、グルタミン酸誘導体であり、次の化学式で表される。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 59-30-3
- EC No.欧盟化学品目录编号
- 200-419-0
- DTXSID美国EPA化学品编号
- DTXSID0022519
- DTXCID美国EPA化合物编号
- DTXCID102519
- IUPAC
- N-(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
- 分子式
- C19H19N7O6
- 分子量
- 441.404 g/mol
实测物性
- 性状
- Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482 °F. · Yellowish-orange solid, [Merck Index] Yellow solid, [Sigma-Aldrich MSDS]
- 气味
- Odorless or almost odorless · 无臭
- 熔点
- 482 °F (decomposes) (NTP, 1992) · 250 °C
- 溶解性
- Almost insoluble (NTP, 1992) · Slightly sol in methanol, less in ethanol and butanol, insol in acetone, chloroform, ether, benzene, relatively sol in acetic acid, phenol, pyridine, and in soln of alkali hydroxides and carbonates. Soluble in hot dil HCl and H2SO4.
- 稳定性
- Aqueous solutions of folic acid are heat sensitive and decompose rapidly in the presence of light and /or riboflavin, solutions should be protected from light. · Inactivated by light with formation of xanthopterinaldehyde, crystalline is stable at 4 °C.
- pH
- A suspension of 1 g of folic acid in 10 ml of water has a pH of 4.0-4.8. Aq solutions prepared with sodium bicarbonate have a pH between 6.5 and 6.8. · 4~4.8
- 解离常数
- pKa = 3.5, 4.3 (carboxylic acid moieties) /Estimated/
- 蒸气压
- (3.37x10-21 mmHg @ 25 ℃, 估算值)
- 溶解度
- 1.6 ㎎/ℓ (Water Solubility 25 ℃)
- 蒸气密度
- 15.24
- 正辛醇/水分配系数（Kow）
- -2.81 (估算值)
- 分解温度
- 250 ℃
- 分子量
- 441.40
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 5 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Softener and conditioner3
- Flavouring and nutrient2
来源: 美国EPA CompTox
相关文献
- Using Inverted Microemulsions for Transdermal Application of Folic Acid · 2019
- Role of folic acid in chlorpyrifos induced teratogenicity in mice · 2014
- Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting · 2010
- Folic acid in general medicine and dermatology · 2007
- Anaphylactic reaction to folic acid verified by provocational testing · 2007