Definition
US FDA substance register · UNII 42BWR07L73 · registered name FORMAMIDINE SULFINIC ACID · single chemical substance
Formamidine Sulfinic Acid is the organic compound
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1758-73-2
- EC No.EU chemical inventory number
- 217-157-8
- DTXSIDUS EPA chemical ID
- DTXSID4029224
- DTXCIDUS EPA compound ID
- DTXCID509224
- IUPAC
- Amino(imino)methanesulfinic acid
- Molecular formula
- CH4N2O2S
- Molecular weight
- 108.12 g/mol
Measured properties
- Appearance
- Thiourea dioxide appears as a white or light-yellow odorless crystalline powder. Mp:126 °C. Soluble in water (27 g / L at room temperature). Decomposes exothermically at temperatures above 126 °C with the emission of noxious gases (sulfur oxides, ammonia, carbon monoxide, nitrogen oxides and hydrogen sulfide) and carbon dioxide. Extended exposure to temperatures above 50 °C and moisture may cause · Dry Powder
- Colour
- white
- Vapour pressure
- 0.0000327 ㎜Hg (at 25C(est.))
- Water solubility
- 1000000 ㎎/ℓ (at 25C(est.))
- n-Octanol/water partition coefficient (Kow)
- 3.37 ((est.))
- Decomposition temperature
- 126 ℃
- Molecular weight
- 108.12
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Reducing agent1
- Dusting agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- Category 2
Skin Irritation · Screening - Category 6.3A (Category 2)
Skin Irritation · Read Across - Ambiguous
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test) adopted in 2004 according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) adopted in 1981 - Classification not possible
Skin Sensitization · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: FDA [Fed. Reg. 28 (119), 5582, 1963] / Draize, Kelley [Drug Cosmet. Industr. 71 (1952) 36] according to - Category 2
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Linked databases 13
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese