Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Definition
Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a plant metabolite and a phytoestrogen. It is a member of 4'-methoxyisoflavones and a member of 7-hydroxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).
Source: PubChem
US FDA substance register · UNII 295DQC67BJ · registered name FORMONONETIN · single chemical substance
Formononetin is the organic compound that conforms to the formula:
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 485-72-3
- EC No.EU chemical inventory number
- 207-623-9
- DTXSIDUS EPA chemical ID
- DTXSID4022311
- DTXCIDUS EPA compound ID
- DTXCID502311
- IUPAC
- 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
- Molecular formula
- C16H12O4
- Molecular weight
- 268.268 g/mol
Measured properties
- Appearance
- Solid
- Melting point
- 256 - 258 °C
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Humectant1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Improving the Solubility of Formononetin and Enabling Hydrogel-Based Wound-Oriented Applications Through the Effect of Hot-Melt Extrusion · 2026
- Network pharmacology analysis and in vitro verification of the anti-sarcopenia effects of formononetin · 2025
- Potential mechanisms of formononetin against inflammation and oxidative stress: a review · 2024
- A comparative study on inclusion complex formation between formononetin and β-cyclodextrin derivatives through multiscale classical and umbrella sampling simulations. · 2023
- Formononetin Inhibits Microglial Inflammatory Response and Contributes to Spinal Cord Injury Repair by Targeting the EGFR/MAPK Pathway · 2023
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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