Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'.
How much products actually contain
No product states its amount yet.
Of the products containing it, 1 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
1 of 1 confirmed · likeliest to carry enough first
Definition
Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as a geroprotector, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a plant metabolite, a phytoestrogen and a human urinary metabolite. It is a conjugate acid of a genistein(1-).
Source: PubChem
US FDA substance register · UNII DH2M523P0H · registered name GENISTEIN · single chemical substance
Genistein is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
European Union
- Maximum concentration in ready for use preparation : 0.007 %
Source: MFDS (Korea) cosmetic regulatory information
EU Cosmetics Regulation, Annex III (restricted substances), entry 373 · maximum concentration 0,007 %
Restriction III/373
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ゲニステイン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 446-72-0
- EC No.EU chemical inventory number
- 207-174-9
- DTXSIDUS EPA chemical ID
- DTXSID5022308
- DTXCIDUS EPA compound ID
- DTXCID002308
- IUPAC
- 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- Molecular formula
- C15H10O5
- Molecular weight
- 270.24 g/mol
Measured properties
- Appearance
- Solid · Rectangular or six-sided rods from 60% alcohol. Dendritic needles from ether
- Melting point
- 301.5 dec °C · 297-298 °C (slight decomposition)
- Solubility
- Soluble in the usual organic solvents, soluble in dilute alkalies with yellow color. Practically insoluble in water.
- Odour
- odourless
- pH
- 7.08
- Melting/freezing point
- 301.5 ℃
- Initial boiling point and range
- 464.36 ℃
- Vapour pressure
- 0.00000000000512 ㎜Hg
- Water solubility
- 258 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 2.84
- Molecular weight
- 270.24
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Development of topical nanoemulsions containing the isoflavone genistein. · 2009
- Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate · 2024
- Genistein - characterization of the molecule, similarity to estradiol and pharmacological potential · 2023
- Changes in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two types of cyclodextrin derivatives · 2012
- Permeation of genistein through human skin · 2003
Linked databases 20
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English · Japanese · Chinese