Ingredient Dictionary

GEROTINE

Spermine is a polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens.

Definition

Spermine is a polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. It has a role as an antioxidant, an immunosuppressive agent and a fundamental metabolite. It is a tetramine and a polyazaalkane. It is a conjugate base of a spermine(4+).

Source: PubChem

US FDA substance register · UNII 2FZ7Y3VOQX · registered name SPERMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction II/411 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

GEROTINEINCI제로틴Korean label name (MFDS standard)

CAS No.chemical registry number: 71-44-3
EC No.EU chemical inventory number: 200-754-2
DTXSIDUS EPA chemical ID: DTXSID9058781
DTXCIDUS EPA compound ID: DTXCID8046872

IUPAC: N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine
Molecular formula: C10H26N4
Molecular weight: 202.346 g/mol

Measured properties

Appearance: solid
Colour: white
Melting/freezing point: 29 ℃
Initial boiling point and range: 141~142 ℃
Flash point: 175 ℃
Flammability (solid, gas): flammable
Vapour pressure: 0.0007 ㎜Hg (at 5 ℃)
Vapour density: 6.98
n-Octanol/water partition coefficient (Kow): -0.68 (est.)
Molecular weight: 202.34

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

SkinIrr2
Skin Irritation · QSAR Predicted
Category 8.2C (Category 1C)
Skin Irritation · Read Across
SkinSens1
Skin Sensitization · QSAR Predicted
Category 8.3A (Category 1)
Eye Irritation · Read Across