Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively.
- Dark spots D
- Amount studies used
- 0.05–0.5%
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
Clinical evidence grade by skin concern
- D
- lab work or a record only
Definition
Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.
Source: PubChem
US FDA substance register · UNII HOC5567T41 · registered name GLABRIDIN · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name グラブリジン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 59870-68-7
- DTXSIDUS EPA chemical ID
- DTXSID00208589
- DTXCIDUS EPA compound ID
- DTXCID00131080
- IUPAC
- 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]benzene-1,3-diol
- Molecular formula
- C20H20O4
- Molecular weight
- 324.376 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Bleaching agent1
Source: US EPA CompTox dashboard
Related literature
- Glabridin-encapsulated liposomes targeting melanocytes through the melanocortin 1 receptor. · 2025
- The inhibitory effects of glabridin on human platelet aggregation and thrombus formation · 2023
- Construction of a monoclonal antibody against glabridin (2G4) and development of an enzyme-linked immunosorbent assay. · 2023
- Study on the fungicidal mechanism of glabridin against Fusarium graminearum. · 2021
- Fabrication and Evaluation of Glabridin Tip-loaded Dissolving Microneedles. · 2021
Linked databases 17
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Chinese