Ingredient Dictionary

GLUCONIC ACID

D-gluconic acid is a gluconic acid having D-configuration.

How much products actually contain

3 products state the amountmedian 0.001%

under 0.01% 2
0.01–0.1% 0
0.1–1% 0
1% or more 1

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 19 list it before the 1% line and 17 after it (usually 1% or less).

Products using this ingredient

12 of 36 confirmed · likeliest to carry enough first · See all 36

Definition

D-gluconic acid is a gluconic acid having D-configuration. It has a role as a chelator and a Penicillium metabolite. It is a conjugate acid of a D-gluconate. It is an enantiomer of a L-gluconic acid.

Source: PubChem

US FDA substance register · UNII R4R8J0Q44B · registered name Gluconic Acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Binds metal ions to prevent spoilageCHELATINGGives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Safety Assessment of Monosaccharides, Disaccharides and Related Ingredients as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name グルコン酸: 本品は、次の化学式で表される有機酸である。

Source: JCIA labelling names (Japan)

Names & identifiers

GLUCONIC ACIDINCI글루코닉애씨드Korean label name (MFDS standard)D-Gluconic acidSynonymグルコン酸Japanese labelling name

CAS No.chemical registry number: 133-42-6
CAS No.chemical registry number: 526-95-4
EC No.EU chemical inventory number: 208-401-4
DTXSIDUS EPA chemical ID: DTXSID8027169
DTXCIDUS EPA compound ID: DTXCID307169

IUPAC: D-Gluconic acid
Molecular formula: C6H12O7
Molecular weight: 196.155 g/mol

Measured properties

Colour: white
Melting/freezing point: 131 ℃
Initial boiling point and range: 417.1 ℃
Vapour pressure: (10.87E-10 hPa at 25°C)
Water solubility: 100 g/100㎖ (1000 g/l at 25°C)
Relative density: 1.24 (at 25 ℃/4 ℃)
n-Octanol/water partition coefficient (Kow): -1.87 (at 25°C)
Molecular weight: 196.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 30 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Chelating agent10
Processing aids not otherwise specified5
Flavouring and nutrient4
Pharmaceutical (EPA)3
Solvent3
Chemical reaction regulator2
Fragrance1
Fixing agent (mordant)1

1 other uses

Solids separation (precipitating) agent, not other1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 2 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) reliability scoring based on 2002 guideline according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) Reliability scoring based on 2002 guideline according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to