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Ingredient Dictionary

GLUCONOLACTONE

D-glucono-1,5-lactone is an aldono-1,5-lactone obtained from D-gluconic acid.

Clinical evidence
  • Lines C
  • Dryness C
  • Pores C
Amount studies used
4–10%
When
evening
Irritation
low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

Molecular structure

How much products actually contain

26 products state the amountmedian 0.5%23% at or above the amount studies used (4–10%)

  • under 0.01% 6
  • 0.01–0.1% 4
  • 0.1–1% 4
  • 1% or more 12

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 428 list it before the 1% line and 570 after it (usually 1% or less).

Where no amount is stated, a product listing it early reaches the study amount about 44% of the time, one listing it late about 2%.

Clinical evidence grade by skin concern

C
uncontrolled or multi-ingredient studies
1 references

Products using this ingredient

12 of 997 confirmed · likeliest to carry enough first · See all 997

Definition

D-glucono-1,5-lactone is an aldono-1,5-lactone obtained from D-gluconic acid. It has a role as an animal metabolite and a mouse metabolite. It is a gluconolactone and an aldono-1,5-lactone. It is functionally related to a D-gluconic acid.

Source: PubChem

US FDA substance register · UNII WQ29KQ9POT · registered name Gluconolactone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

D-Glucono-1,5-lactone

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGBinds metal ions to prevent spoilageCHELATING

Safety & regulatory references

Canada

  • Conditions of Use by product type : (a) Products for use on the skin for consumer use. Manufacturer or importer to provide pH levels. (b) Products for use on the skin for professional use: Manufacturer must provide Health Canada with evidence of safety including: 1. pH levels 2. AHA concentrations 3. Directions for use 4. Clinical studies demonstrating minimal skin irritation (c) Products intended to be diluted in bath water may contain levels of AHAs exceeding 10% (d) Other cosmetics (e) Any cosmetics
  • Maximum Concentration Permitted : (a) Between 3% and 18% total mono-AHA equivalents with a pH equal to or greater than 3.5 (b) Between 18% and 30% total mono-AHA equivalents and/or a pH between 3.0 to 3.5 (d) Between 3% and 30% total mono-AHA equivalents with a pH equal to or greater than 3.0 (e) 3%
  • Warnings and Cautionary Statements: (to the effect of) : (a) and (b) : "Use only as directed", "Avoid contact with the eyes", "If irritation persists, discontinue use and consult a physician", "It is recommended that prior to exposure to the sun, users cover areas where AHAs have been applied with sunscreen" Product labels should contain appropriate directions regarding frequency and/or duration of use. (b only) "For professional use only" (d) "Use only as directed", "Avoid contact with eyes", "Discontinue use if rash or irritation occurs"

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Glycolactones as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name グルコノラクトン: 本品は、次の化学式で表されるラクトンである。

Source: JCIA labelling names (Japan)

Names & identifiers

GLUCONOLACTONEINCI글루코노락톤Korean label name (MFDS standard)D-Gluconic acid, .delta.-lactoneSynonymグルコノラクトンJapanese labelling name
CAS No.chemical registry number
90-80-2
EC No.EU chemical inventory number
202-016-5
DTXSIDUS EPA chemical ID
DTXSID0026549
DTXCIDUS EPA compound ID
DTXCID406549
IUPAC
(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-one (non-preferred name)
Molecular formula
C6H10O6
Molecular weight
178.14 g/mol

Measured properties

Appearance
Dry Powder, Other Solid · Fine, white, nearly odourless, crystalline powder
Melting point
155 °C /decomposes/ · 151 - 155 °C
Solubility
590000 mg/L (at 25 °C) · Freely soluble in water. Sparingly soluble in ethanol
Density
1.610 g/cu cm at -5 °C
pH
Freshly prepared aqueous solution has pH of 3.6, changing to 2.5 within 2 hours · 2.5~3.6
Colour
white
Vapour pressure
0 hPa (@ 20 ℃)
Water solubility
590000 ㎎/ℓ (@ 25 ℃)
Vapour density
6.15
Relative density
1.610 (@ -5 ℃)
n-Octanol/water partition coefficient (Kow)
-1.98
Decomposition temperature
155 ℃
Molecular weight
174.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 52 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Softener and conditioner29
  • Chelating agent5
  • Processing aids not otherwise specified4
  • pH regulating agent2
  • Humectant2
  • Flavouring and nutrient2
  • Chemical reaction regulator1
  • Preservative1
6 other uses
  • Antioxidant1
  • Fragrance1
  • Solvent1
  • Leavening agent (EPA)1
  • Food preservative (EPA)1
  • Intermediate1

Source: US EPA CompTox dashboard

Related literature

Linked databases 22

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