L-glutamic acid is an optically active form of glutamic acid having L-configuration.
How much products actually contain
12 products state the amountmedian 0.00013%
- under 0.01% 10
- 0.01–0.1% 2
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 153 list it before the 1% line and 556 after it (usually 1% or less).
Products using this ingredient
12 of 707 confirmed · likeliest to carry enough first · See all 707
ElastineAmino Peptide Weak Acid Protein High Nutrition Shampoo Pear & Freesia Scent0.00032% stated
NativeNative Curl Care Conditioner
NativeNative Daily Clean Conditioner
NativeNative Daily Clean Conditioner - Last Chance
NativeNative Mini Moisturizing Conditioner
NativeNative Mini Volumizing Conditioner
NativeNative Moisturizing Conditioner
NativeNative Moisturizing Conditioner - Last Chance
NativeNative Strengthening Conditioner
NativeNative Strengthening Hair Mask
NativeNative Volumizing Conditioner
NativeNative Volumizing Conditioner - Last Chance
Definition
L-glutamic acid is an optically active form of glutamic acid having L-configuration. It has a role as a ferroptosis inducer, a neurotransmitter, a micronutrient, a nutraceutical, a mouse metabolite and an Escherichia coli metabolite. It is a L-alpha-amino acid, a glutamic acid, a glutamine family amino acid and a proteinogenic amino acid. It is a conjugate acid of a L-glutamate(1-). It is an enantiomer of a D-glutamic acid.
Source: PubChem
US FDA substance register · UNII 3KX376GY7L · registered name Glutamic Acid · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Safety Assessment of alpha-Amino Acids as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name グルタミン酸: 本品は、次の化学式で表されるアミノ酸である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 6899-05-4
- CAS No.chemical registry number
- 617-65-2
- CAS No.chemical registry number
- 6893-26-1
- CAS No.chemical registry number
- 56-86-0
- EC No.EU chemical inventory number
- 200-293-7
- DTXSIDUS EPA chemical ID
- DTXSID5020659
- DTXCIDUS EPA compound ID
- DTXCID30659
- IUPAC
- L-Glutamic acid
- Molecular formula
- C5H9NO4
- Molecular weight
- 147.13 g/mol
Measured properties
- Appearance
- Large Crystals · White crystals or crystalline powder
- Odour
- Odorless
- Boiling point
- Sublimes at 175 °C
- Melting point
- 224 dec °C · 213 °C (OECD Guideline 102 (Melting point / Melting Range))
- Solubility
- 8570 mg/L (at 25 °C) · Sparingly soluble in water, practically insoluble in ethanol or ether
- Density
- 1.538 g/cu cm at 20 °C
- Stability
- Stable under recommended storage conditions. /L-Glutamic acid hydrochloride/
- pH
- Between 3,0 and 3,5 (saturated solution) · Aqueous solutions have pH values of approximately 2
- Dissociation constant
- 2.23 (at 0 °C) · pK1: 2.19, pK2: 4.25, pK3: 9.67
- Melting/freezing point
- 160 ℃
- Initial boiling point and range
- 175 ℃
- Flash point
- 520 ℉
- Vapour pressure
- 268000000000 ㎜Hg
- Water solubility
- 8640 ㎎/ℓ
- Relative density
- 1.538 (at 20/4 ℃)
- n-Octanol/water partition coefficient (Kow)
- -3.69
- Auto-ignition temperature
- 640 ℃
- Decomposition temperature
- 224 ℃
- Molecular weight
- 147.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Soil amendments3
- Flavouring and nutrient2
- pH regulating agent1
- Softener and conditioner1
- Humectant1
- Anti-static agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Glutamic-Acid Grafted Hyaluronic Acid Inhibits Inflammatory Factors via Fibroblast and Skin Model Tests · 2024
- Glutamic acid promotes hair growth in mice · 2021
- Glutamic acid promotes hair growth in mice · 2020
- Development of chitosan/poly-γ-glutamic acid/pluronic/curcumin nanoparticles in chitosan dressings for wound regeneration. · 2017
- γ-Poly glutamic acid : A novel peptide for skin care · 2007
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata