Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.
- Korean limit
- 0.1%
Definition
US FDA substance register · UNII T3C89M417N · registered name GLUTARAL · single chemical substance
Glutaral is the dialdehyde that conforms to the formula:
Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. It has a role as a disinfectant, a cross-linking reagent and a fixative.
Source: PubChem
Cosmetic roles
Safety & regulatory references
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.1%
- Other limitations and requirements : Banned in sprayable systems such as aerosols and sprays
- Use conditions and warnings that must appear on the label : Contains glutaraldehyde (for concentrations greater than 0.05% in the finished product only)
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.1%
- Other limitations and requirements : Prohibited in aerosols (sprays)
- Conditions of use and warning which must be printed on the labels : - Contains glutaraldehyde (where glutaraldehyde concentration in the finished product exceeds 0.05%)
Taiwan
- Maximum concentration : 0.1%
- 0.1%
China · South Korea
- Maximum concentration : 0.1%
European Union
- Maximum concentration in ready for use preparation : 0.1%
- Other : Not to be used in aerosols (sprays)
- Wording of conditions of use and warnings : Contains glutaral (9)
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H411 (category 2) · H301 (category 3) · H317 (category 1A) · +5 more
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 48 · maximum concentration 0.1%
Restriction V/48 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Glutaral
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 111-30-8
- EC No.EU chemical inventory number
- 203-856-5
- DTXSIDUS EPA chemical ID
- DTXSID6025355
- DTXCIDUS EPA compound ID
- DTXCID605355
- IUPAC
- Pentanedial
- Molecular formula
- C5H8O2
- Molecular weight
- 100.117 g/mol
Measured properties
- Appearance
- Glutaraldehyde solution is a light yellow liquid. Mixes with water. (USCG, 1999) · Dry Powder, Liquid
- Odour
- Pungent odor · Sweetish
- Boiling point
- 369 to 372 °F at 760 mmHg (decomposes) (NTP, 1992) · 187-189 °C (decomposes)
- Melting point
- less than 20 °F (USCG, 1999) · Freezing point: -14 °C
- Solubility
- greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) · Miscible with water
- Density
- 1.062 to 1.124 at 68 °F (USCG, 1999) · 0.72
- Colour
- colourless
- Melting/freezing point
- -33 ℃
- Initial boiling point and range
- 102 ℃
- Flash point
- 95 ℃
- Vapour pressure
- 2.3 ㎪ (20℃)
- Water solubility
- 100 ㎎/ℓ (72° F)
- Vapour density
- 3.5
- Relative density
- 1.13 (20℃)
- n-Octanol/water partition coefficient (Kow)
- -0.36 (at 23℃, pH7 EU Method A.8)
- Auto-ignition temperature
- 395 ℃ (at 1013 hPa)
- Viscosity
- 12.75 (25℃)
- Molecular weight
- 100.12
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 117 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative88
- Biocide9
- Processing aids not otherwise specified7
- Pigment2
- Fragrance2
- Brightener2
- Hardener1
- Tanning agents not otherwise specified1
5 other uses
- Anti-scaling agent1
- Oxidizing agent1
- Flavouring and nutrient1
- Intermediate1
- Embalming agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
21 skin studies and 11 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 32 studies
- Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Sah
Skin Sensitization · Authoritative - Skin Corr. 1B
Skin Irritation · Authoritative - Corrosive
skin irritation: in vivo · Screening · other guideline: EPA 40 CFR 183 according to - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Draize Test according to - Skin Sens. 1A
Skin Sensitization · Authoritative - Skin Sens. 1
Skin Sensitization · Screening - Skin Corr. 1B
Skin Irritation · Screening - Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 8.2B (Category 1B)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Skin sensitization - Category 1A
Skin Sensitization · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 1
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Category 6.3A (Category 2)
Skin Irritation · Read Across - Ambiguous
skin irritation: in vivo · Screening · other guideline: in vivo rabbit skin test method for corrosion, specified by the U.S. Dept. of Transportation (DOT). equivalent or similar to - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (adopted 1981) according to - Corrosive
skin irritation: in vivo · Screening · other guideline: in vivo rabbit skin test method for corrosion, specified by the U.S. Dept. of Transportation (DOT). equivalent or similar to - Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (as adopted 1981) equivalent or similar to - Eye Dam. 1
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Severe Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Fed. Reg. 38, No. 187, s 1500.42, p. 27019 of Sept. 27, 1973 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test equivalent or similar to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Draize Test according to - Severe Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test equivalent or similar to - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
Linked databases 28
- AICIS inventory notices (Australia)
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English · Japanese · Chinese