この成分は何ですか?

이 원료는 다음의 구조를 갖는 다이알데하이드이다.

成分一覧

成分辞典

GLUTARAL

Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.

韓国の配合上限: 0.1%

定義

米国FDA 物質登録 · UNII T3C89M417N · 登録名 GLUTARAL · 単一の化学物質

出典: 米国FDA 物質識別番号（UNII）

Glutaral is the dialdehyde that conforms to the formula:

Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. It has a role as a disinfectant, a cross-linking reagent and a fixative.

出典: PubChem

化粧品での役割

製品中の微生物の増殖を防ぐPRESERVATIVE香料組成に使う物質として登録（香りを出すという意味ではありません）FRAGRANCE

安全性・規制情報

許可された防腐剤: イギリス

出典: ASEAN 化粧品指令 · EU 化粧品規則 · 台湾FDA 化粧品成分 · 英国化粧品規則

アルゼンチン · ブラジル

Maximum concentration permitted at final product : 0.1%
Other limitations and requirements : Banned in sprayable systems such as aerosols and sprays
Use conditions and warnings that must appear on the label : Contains glutaraldehyde (for concentrations greater than 0.05% in the finished product only)

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.1%
Other limitations and requirements : Prohibited in aerosols (sprays)
Conditions of use and warning which must be printed on the labels : - Contains glutaraldehyde (where glutaraldehyde concentration in the finished product exceeds 0.05%)

台湾

倘前述三國家地區政府管理有差異時，則採其中限量規定方式最安全者。
※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
用途 : 防腐
最大配合量 : 0.1%
不得使用於噴霧類產品
0.1%

中国 · 韓国

最大配合量 : 0.1%

欧州連合

Maximum concentration in ready for use preparation : 0.1%
Other : Not to be used in aerosols (sprays)
Wording of conditions of use and warnings : Contains glutaral (9)

出典: 韓国食薬処化粧品規制情報

韓国の有害物質GHS分類: 危険 · H411 (区分2) · H301 (区分3) · H317 (区分1A) · ほか5件

出典: 韓国有害物質GHS情報（環境公団）

EU化粧品規則附属書V（許可防腐剤）第48項 · 最大濃度 0.1%

出典: EU 許可防腐剤（附属書V）

Restriction V/48 · Other restriction: ban substances that deplete the ozone layer

出典: EU CosIng 成分リスト

Reviewed by CIR: Final Report on the Safety Assessment of Glutaral

出典: 米国CIR 安全性評価

Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015

出典: 米国CIR 安全性評価

詳しい資料 — 表示名・識別番号・物性・試験記録・文献

別名・識別情報

GLUTARALINCI글루타랄韓国の表示名（食薬処標準名）글루타랄(펜탄-1,5-디알)韓国の表示名（食薬処標準名）Pentanedial別名

CAS No.化学物質登録番号: 111-30-8
EC No.EU化学物質目録番号: 203-856-5
DTXSID米国EPA化学物質番号: DTXSID6025355
DTXCID米国EPA化合物番号: DTXCID605355

IUPAC: Pentanedial
分子式: C5H8O2
分子量: 100.117 g/mol

測定された物性

性状: Glutaraldehyde solution is a light yellow liquid. Mixes with water. (USCG, 1999) · Dry Powder, Liquid
臭い: Pungent odor · Sweetish
沸点: 369 to 372 °F at 760 mmHg (decomposes) (NTP, 1992) · 187-189 °C (decomposes)
融点: less than 20 °F (USCG, 1999) · Freezing point: -14 °C
溶解性: greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) · Miscible with water
密度: 1.062 to 1.124 at 68 °F (USCG, 1999) · 0.72
色: 無色
融点・凝固点: -33 ℃
初留点および沸点範囲: 102 ℃
引火点: 95 ℃
蒸気圧: 2.3 ㎪ (20℃)
溶解度: 100 ㎎/ℓ (72° F)
蒸気密度: 3.5
比重: 1.13 (20℃)
n-オクタノール/水分配係数（Kow）: -0.36 (at 23℃, pH7 EU Method A.8)
自然発火温度: 395 ℃ (at 1013 hPa)
粘度: 12.75 (25℃)
分子量: 100.12

物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。

出典: PubChem · 韓国安全保健公団 SDS

製品が実際に使っている用途

米国EPAにこの成分を届け出た製品117件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。

Preservative88
Biocide9
Processing aids not otherwise specified7
Pigment2
Fragrance2
Brightener2
Hardener1
Tanning agents not otherwise specified1

その他の用途 5件

Anti-scaling agent1
Oxidizing agent1
Flavouring and nutrient1
Intermediate1
Embalming agent1

出典: 米国EPA CompTox

刺激・感作試験の記録

皮膚試験21件・眼試験11件の記録があります。

刺激が強いと分類2件

試験の結論はおおむね一致しています（100%）。原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。

試験32件をすべて見る

Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Sah
Skin Sensitization · Authoritative
Skin Corr. 1B
Skin Irritation · Authoritative
Corrosive
skin irritation: in vivo · Screening · other guideline: EPA 40 CFR 183 according to
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Draize Test according to
Skin Sens. 1A
Skin Sensitization · Authoritative
Skin Sens. 1
Skin Sensitization · Screening
Skin Corr. 1B
Skin Irritation · Screening
Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Category 8.2B (Category 1B)
Skin Irritation · Read Across
Skin corrosion/irritation - Category 1
Skin Irritation · Screening
Skin sensitization - Category 1A
Skin Sensitization · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 1
Skin Irritation · Screening
Category 1
Skin Sensitization · Screening
Category 6.3A (Category 2)
Skin Irritation · Read Across
Ambiguous
skin irritation: in vivo · Screening · other guideline: in vivo rabbit skin test method for corrosion, specified by the U.S. Dept. of Transportation (DOT). equivalent or similar to
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (adopted 1981) according to
Corrosive
skin irritation: in vivo · Screening · other guideline: in vivo rabbit skin test method for corrosion, specified by the U.S. Dept. of Transportation (DOT). equivalent or similar to
Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (as adopted 1981) equivalent or similar to
Eye Dam. 1
Eye Irritation · Screening
Severe Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test according to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Severe Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Fed. Reg. 38, No. 187, s 1500.42, p. 27019 of Sept. 27, 1973 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test equivalent or similar to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Draize Test according to
Severe Irritation
eye irritation: in vivo · Screening · other guideline: Draize Test equivalent or similar to
Category 8.3A (Category 1)
Eye Irritation · Read Across
Category 1
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across