Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol.
Definición
Registro de sustancias de la FDA (EE. UU.) · UNII 0FWE72AF2P · nombre registrado GLYCERYL MONOTHIOGLYCOLATE · mezcla
Fuente: Identificador único de ingredientes de la FDA (UNII)
Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen.
Fuente: PubChem
Mercaptoacetic acid, monoester with propane-1,2,3-triol
Funciones cosméticas
Referencias de seguridad y regulación
- Restringido
- China
Fuente: Información regulatoria cosmética del MFDS (Corea)
Argentina · Brasil
- Field of application and/or use : Products for straightening or waving hair: 1. General use 2. Professional use
- Maximum concentration permitted at final product : 1. 8% ready to use pH 6 to 9,5 2.11% ready to use pH 6 to 9.5 The percentages are calculated as thioglycolic acid
- Other limitations and requirements : 1) and 2) In the USAGE must consist obligatorily the following information: - May cause sensitization by skin contact. - Avoid contact with eyes. - In case of contact with eyes, rinse immediately and thoroughly with water and consult a doctor. - Wear suitable gloves
- Use conditions and warnings that must appear on the label : 1) and 2) Contains thioglycolate Follow the instructions Keep out of reach of children. For professional use only (if applicable)
ASEAN
- Field of application and/or use : Hair waving or straightening products: 1. General use 2. Professional use
- Maximum authorised concentration in the finished cosmetic product : 1. 8% ready for use at pH 6-9.5 2. 11% ready for use at pH 6-9.5 Percentages calculated as thioglycolic acid.
- Other limitations and requirements : The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • May cause sensitisation in the event of skin contact. • Avoid contact with eyes. • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves.
- Conditions of use and warning which must be printed on the labels : • Contains thioglycolate. • Follow the instructions. • Keep out of reach of children. • For professional use only.
Unión Europea
- Product Type, body parts : Hair waving or straightening products
- Maximum concentration in ready for use preparation : (a) 8% (b) 11% The abovementioned percentages are calculated as thioglycollic acid
- Other : (a) General use ready for use pH 6 to 9.5 (b) Professional use ready for use pH 6 to 9.5
- Wording of conditions of use and warnings : Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable gloves Warnings: Contains thioglycolate Follow the instructions Keep out of reach of children (b) For professional use only
Fuente: Información regulatoria cosmética del MFDS (Corea)
Sin clasificación en la lista GHS de sustancias tóxicas de Corea
Lista de ingredientes cosméticos de Health Canada · prohibido en cosméticos
Restriction III/2b
Reviewed by CIR: Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres y definiciones oficiales
Nombre de etiquetado de la JCIA チオグリコール酸グリセリル: 本品は、チオグリコール酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
Nombres e identificadores
- CAS No.número de registro químico
- 30618-84-9
- EC No.número de inventario químico de la UE
- 250-264-8
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID2027965
Propiedades medidas
- Aspecto
- Colorless viscous liquid with a mild sulfurous odor, [Lanza Research MSDS]
Valores medidos en la sustancia en sí, no una especificación de una materia prima comercial.
Fuente: PubChem
Para qué lo usan los productos
Usos de los 1 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Hair waving or straightening (EPA)1
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 6 estudios en piel y 2 en ojos.
Los estudios no coinciden (la conclusión más frecuente reúne el 25%), así que no demuestran que el ingrediente sea irritante. Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 8 estudios
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - SkinSens1
Skin Sensitization · QSAR Predicted - Sh
Skin Sensitization · Authoritative - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.3A (Category 2)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Potassium peroxymonosulfate‐induced dermatitis in a sheep farmer · 1999
- P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms. · 2026
- North American Contact Dermatitis Group Patch Test Results: 2009 to 2010 · 2013
- Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thio · 2009
- Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid · 1991
Bases de datos vinculadas 19
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- ChEBI
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- Lista de ingredientes restringidos de Health Canada
- Nombres de etiquetado de la JCIA (Japón)
- Panel CompTox de la EPA
- PubChem 2
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Wikidata