GLYCERYL THIOGLYCOLATE
Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol.
定義
米国FDA 物質登録 · UNII 0FWE72AF2P · 登録名 GLYCERYL MONOTHIOGLYCOLATE · 混合物
Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen.
出典: PubChem
Mercaptoacetic acid, monoester with propane-1,2,3-triol
化粧品での役割
安全性・規制情報
- 制限
- 中国
出典: 韓国食薬処 化粧品規制情報
アルゼンチン · ブラジル
- Field of application and/or use : Products for straightening or waving hair: 1. General use 2. Professional use
- Maximum concentration permitted at final product : 1. 8% ready to use pH 6 to 9,5 2.11% ready to use pH 6 to 9.5 The percentages are calculated as thioglycolic acid
- Other limitations and requirements : 1) and 2) In the USAGE must consist obligatorily the following information: - May cause sensitization by skin contact. - Avoid contact with eyes. - In case of contact with eyes, rinse immediately and thoroughly with water and consult a doctor. - Wear suitable gloves
- Use conditions and warnings that must appear on the label : 1) and 2) Contains thioglycolate Follow the instructions Keep out of reach of children. For professional use only (if applicable)
ASEAN
- Field of application and/or use : Hair waving or straightening products: 1. General use 2. Professional use
- Maximum authorised concentration in the finished cosmetic product : 1. 8% ready for use at pH 6-9.5 2. 11% ready for use at pH 6-9.5 Percentages calculated as thioglycolic acid.
- Other limitations and requirements : The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • May cause sensitisation in the event of skin contact. • Avoid contact with eyes. • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves.
- Conditions of use and warning which must be printed on the labels : • Contains thioglycolate. • Follow the instructions. • Keep out of reach of children. • For professional use only.
欧州連合
- Product Type, body parts : Hair waving or straightening products
- Maximum concentration in ready for use preparation : (a) 8% (b) 11% The abovementioned percentages are calculated as thioglycollic acid
- Other : (a) General use ready for use pH 6 to 9.5 (b) Professional use ready for use pH 6 to 9.5
- Wording of conditions of use and warnings : Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable gloves Warnings: Contains thioglycolate Follow the instructions Keep out of reach of children (b) For professional use only
出典: 韓国食薬処 化粧品規制情報
韓国の有害物質GHS分類なし
カナダ化粧品成分ホットリスト · 化粧品への使用禁止
出典: カナダ 禁止・制限成分リスト
Restriction III/2b
出典: EU CosIng 成分リスト
Reviewed by CIR: Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
出典: 米国CIR 安全性評価
Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
出典: 米国CIR 安全性評価
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
公式表示名・定義
日本化粧品工業会の表示名称 チオグリコール酸グリセリル: 本品は、チオグリコール酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
出典: 日本化粧品工業会 表示名称
別名・識別情報
- CAS No.化学物質登録番号
- 30618-84-9
- EC No.EU化学物質目録番号
- 250-264-8
- DTXSID米国EPA化学物質番号
- DTXSID2027965
測定された物性
- 性状
- Colorless viscous liquid with a mild sulfurous odor, [Lanza Research MSDS]
物質そのものを測定した値で、原料商品の規格ではありません。
出典: PubChem
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品1件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Hair waving or straightening (EPA)1
出典: 米国EPA CompTox
刺激・感作試験の記録
皮膚試験6件・眼試験2件の記録があります。
試験ごとに結論が分かれています(最も多い結論の割合 25%)。この成分が刺激性だとは言い切れないということです。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験8件をすべて見る
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - SkinSens1
Skin Sensitization · QSAR Predicted - Sh
Skin Sensitization · Authoritative - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.3A (Category 2)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
出典: 米国EPA CompTox
関連文献
- Potassium peroxymonosulfate‐induced dermatitis in a sheep farmer · 1999
- P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms. · 2026
- North American Contact Dermatitis Group Patch Test Results: 2009 to 2010 · 2013
- Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thio · 2009
- Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid · 1991