Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol.
定义
美国FDA 物质登记 · UNII 0FWE72AF2P · 登记名称 GLYCERYL MONOTHIOGLYCOLATE · 混合物
Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen.
来源: PubChem
Mercaptoacetic acid, monoester with propane-1,2,3-triol
化妆品中的作用
安全与法规参考
- 限用
- 中国
来源: 韩国食药处 化妆品法规信息
阿根廷 · 巴西
- Field of application and/or use : Products for straightening or waving hair: 1. General use 2. Professional use
- Maximum concentration permitted at final product : 1. 8% ready to use pH 6 to 9,5 2.11% ready to use pH 6 to 9.5 The percentages are calculated as thioglycolic acid
- Other limitations and requirements : 1) and 2) In the USAGE must consist obligatorily the following information: - May cause sensitization by skin contact. - Avoid contact with eyes. - In case of contact with eyes, rinse immediately and thoroughly with water and consult a doctor. - Wear suitable gloves
- Use conditions and warnings that must appear on the label : 1) and 2) Contains thioglycolate Follow the instructions Keep out of reach of children. For professional use only (if applicable)
东盟
- Field of application and/or use : Hair waving or straightening products: 1. General use 2. Professional use
- Maximum authorised concentration in the finished cosmetic product : 1. 8% ready for use at pH 6-9.5 2. 11% ready for use at pH 6-9.5 Percentages calculated as thioglycolic acid.
- Other limitations and requirements : The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • May cause sensitisation in the event of skin contact. • Avoid contact with eyes. • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves.
- Conditions of use and warning which must be printed on the labels : • Contains thioglycolate. • Follow the instructions. • Keep out of reach of children. • For professional use only.
欧盟
- Product Type, body parts : Hair waving or straightening products
- Maximum concentration in ready for use preparation : (a) 8% (b) 11% The abovementioned percentages are calculated as thioglycollic acid
- Other : (a) General use ready for use pH 6 to 9.5 (b) Professional use ready for use pH 6 to 9.5
- Wording of conditions of use and warnings : Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable gloves Warnings: Contains thioglycolate Follow the instructions Keep out of reach of children (b) For professional use only
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类
加拿大化妆品成分热点清单 · 禁止用于化妆品
来源: 加拿大禁用·限用成分清单
Restriction III/2b
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 チオグリコール酸グリセリル: 本品は、チオグリコール酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 30618-84-9
- EC No.欧盟化学品目录编号
- 250-264-8
- DTXSID美国EPA化学品编号
- DTXSID2027965
实测物性
- 性状
- Colorless viscous liquid with a mild sulfurous odor, [Lanza Research MSDS]
这是对物质本身测得的数值,并非原料商品的规格。
来源: PubChem
产品实际使用的用途
这是向美国 EPA 申报含该成分的 1 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Hair waving or straightening (EPA)1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 6 项、眼部试验 2 项。
各项试验结论不一(最多的结论占 25%),因此不能断定该成分有刺激性。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 8 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - SkinSens1
Skin Sensitization · QSAR Predicted - Sh
Skin Sensitization · Authoritative - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.3A (Category 2)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
来源: 美国EPA CompTox
相关文献
- Potassium peroxymonosulfate‐induced dermatitis in a sheep farmer · 1999
- P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms. · 2026
- North American Contact Dermatitis Group Patch Test Results: 2009 to 2010 · 2013
- Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thio · 2009
- Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid · 1991