Are there usage precautions?

피부 보습과 탄력 개선피부 장벽 강화 피부 노화 방지

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Ingredient Dictionary

GLYCINE

Glycine is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.

How much products actually contain

12 products state the amountmedian 0.00061%

under 0.01% 10
0.01–0.1% 0
0.1–1% 0
1% or more 2

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 225 list it before the 1% line and 677 after it (usually 1% or less).

Products using this ingredient

12 of 894 confirmed · likeliest to carry enough first · See all 894

Definition

Glycine is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. It has a role as a neurotransmitter, a micronutrient, a nutraceutical, a hepatoprotective agent, an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor, a NMDA receptor agonist and a fundamental metabolite. It is a serine family amino acid, an alpha-amino acid and a proteinogenic amino acid. It is a conjugate base of a glycinium. It is a conjugate acid of a glycinate. It is a tautomer of a glycine zwitterion.

Source: PubChem

US FDA substance register · UNII TE7660XO1C · registered name Glycine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Softens hairHAIR CONDITIONINGKeeps pH steadyBUFFERINGReduces staticANTISTATICKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of alpha-Amino Acids as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name グリシン: 本品は、次の化学式で表されるアミノ酸である。

Source: JCIA labelling names (Japan)

Names & identifiers

GLYCINEINCI글라이신Korean label name (MFDS standard)グリシンJapanese labelling name

CAS No.chemical registry number: 56-40-6
EC No.EU chemical inventory number: 200-272-2
DTXSIDUS EPA chemical ID: DTXSID9020667
DTXCIDUS EPA compound ID: DTXCID90667

IUPAC: Glycine
Molecular formula: C2H5NO2
Molecular weight: 75.067 g/mol

Measured properties

Appearance: Glycine appears as white crystals. (NTP, 1992) · Dry Powder, CBI, Large Crystals, Liquid, Other Solid
Odour: Odorless · odourless
Melting point: 451 °F (NTP, 1992) · 262 dec °C
Solubility: greater than or equal to 100 mg/mL at 64 °F (NTP, 1992) · 249000 mg/L (at 25 °C)
Density: 1.1607 (NTP, 1992) - Denser than water, will sink · 1.161 g/cu cm @ 20 °C
pH: 0.2 molar soln in water: 4.0 · 4
Dissociation constant: 9.8 · 2.37 (at 20 °C)
Colour: white
Vapour pressure: 0.000000128 ㎜Hg (@ 25 ℃, est.)
Water solubility: 249000 ㎎/ℓ (Water Solubility 25 ℃)
Vapour density: 2.59
Relative density: 1.161 (g/cu cm @ 20 ℃)
n-Octanol/water partition coefficient (Kow): -3.21
Decomposition temperature: 262 ℃
Molecular weight: 75.07

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 44 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner10
Flavouring and nutrient6
pH regulating agent6
Anti-static agent4
Humectant3
Solvent2
Processing aids not otherwise specified2
Chelating agent2

9 other uses

Fragrance1
Intermediate1
Antioxidant1
Binder1
Filler1
Surfactant (surface active agent)1
Abrasive1
Plating agent1
Soil amendments1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to