2-hydroxyethyl salicylate is a benzoate ester obtained by the formal condensation of carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol.
Definition
2-hydroxyethyl salicylate is a benzoate ester obtained by the formal condensation of carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is a primary alcohol, a member of salicylates and a member of phenols. It is functionally related to a salicylic acid and an ethylene glycol.
Source: PubChem
US FDA substance register · UNII 3I1VBB7AXH · registered name GLYCOL SALICYLATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name サリチル酸グリコール: 本品は、サリチル酸（＊）とグリコール（＊）のモノエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 87-28-5
- EC No.EU chemical inventory number
- 201-737-2
- DTXSIDUS EPA chemical ID
- DTXSID4048987
- DTXCIDUS EPA compound ID
- DTXCID4028913
- IUPAC
- 2-Hydroxyethyl 2-hydroxybenzoate
- Molecular formula
- C9H10O4
- Molecular weight
- 182.175 g/mol
Measured properties
- Boiling point
- 166
- Melting point
- 25
- Solubility
- 13.1 g/L
- Appearance
- solid
- Colour
- colourless
- Odour
- odourless
- Melting/freezing point
- 37 ℃
- Initial boiling point and range
- 169~172 ℃ (at 12 mmHg)
- Water solubility
- 12700 ㎎/ℓ (@ 20 ℃)
- Vapour density
- 6.29
- Relative density
- 1.244-1.25
- n-Octanol/water partition coefficient (Kow)
- 1.63 (est.)
- Molecular weight
- 182.18
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- UV stabilizer1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3A (Category 2)
Skin Irritation · Read Across - SkinIrr2
Skin Irritation · QSAR Predicted - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata