Glycyrrhizinic acid is a triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.
How much products actually contain
1 products state the amountmedian 0.01%
- under 0.01% 0
- 0.01–0.1% 1
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 3 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
4 of 4 confirmed · likeliest to carry enough first
Definition
Glycyrrhizinic acid is a triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. It has a role as an EC 3.4.21.5 (thrombin) inhibitor and a plant metabolite. It is a glucosiduronic acid, a pentacyclic triterpenoid, a tricarboxylic acid, an enone and a triterpenoid saponin. It is a conjugate acid of a glycyrrhizinate(3-).
Source: PubChem
US FDA substance register · UNII 6FO62043WK · registered name GLYCYRRHIZIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Glycyrrhetinyl Stearate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name グリチルリチン酸: 本品は、カンゾウ Glycyrrhiza glabra から得られる配糖体であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 1405-86-3
- EC No.EU chemical inventory number
- 215-785-7
- DTXSIDUS EPA chemical ID
- DTXSID8047006
- DTXCIDUS EPA compound ID
- DTXCID6027006
- IUPAC
- 30-Hydroxy-11,30-dioxoolean-12-en-3beta-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
- Molecular formula
- C42H62O16
- Molecular weight
- 822.942 g/mol
Measured properties
- Odour
- Intensely sweet taste
- Melting/freezing point
- 220 ℃(EXP)
- Vapour pressure
- (5.22E-34 mm Hg 25℃(EST))
- Water solubility
- 0.053 ㎎/ℓ (25℃ EST)
- n-Octanol/water partition coefficient (Kow)
- 2.8 (EXP)
- Molecular weight
- 822.94
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Humectant2
- Flavouring and nutrient2
- Fragrance1
Source: US EPA CompTox dashboard
Related literature
- Research Progress of Glycyrrhizic Acid on Antiviral Activity. · 2019
- Discovery and Mechanistic Elucidation of Glycyrrhizic Acid Composite Gel in Promoting Wound Healing: A Modernized Study Based on Shengji Yuhong Ointment · 2025
- Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER) · 2020
- Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- and Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma In Vitro and In Vivo. · 2020
- Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice · 2019
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese