Definition
US FDA substance register · UNII 3YQC9ZY4YB · registered name Guanidine Hydrochloride · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name グアニジンＨＣｌ: 本品は、グアニジンの塩酸塩であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 50-01-1
- EC No.EU chemical inventory number
- 200-002-3
- DTXSIDUS EPA chemical ID
- DTXSID7058757
- DTXCIDUS EPA compound ID
- DTXCID4040763
- IUPAC
- Guanidine--hydrogen chloride (1/1)
- Molecular formula
- CH6ClN3
- Molecular weight
- 95.53 g/mol
Measured properties
- Odour
- odourless
- pH
- 6.2
- Melting/freezing point
- 178~185 ℃
- Vapour pressure
- 0.00000176 ㎜Hg (25℃ (est.))
- Water solubility
- 215 g/100㎖ (20℃)
- Relative density
- 1.3
- n-Octanol/water partition coefficient (Kow)
- -1.7
- Molecular weight
- 95.5
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- pH regulating agent2
- Plating agent1
- Flame retardant1
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Category 2
Skin Irritation · Screening - Skin Irrit. 2
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) according to other guideline: EPA TS-792 Dermal sensitisation. Health effects test guidelines, EPA, August 1982; EPA 560/6-82-001 - Severe Irritation
skin irritation: in vivo · Screening · other guideline: EPA TS-792 Dermal irritation. Health effects test guidelines, EPA, August 1982; EPA 560/6-82-001 according to - Category 2A
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · other guideline: EPA 560/6-82-001 (Primary Eye Irritation), August 1982 according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Identification of some components of basal lamina of avian ovarian follicle. · 2000
- Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. · 1996
- The isolation and primary structure of a 22-kDa extracellular matrix protein from bovine skin. · 1989
- Copurification of osteolytic and transforming growth factor beta activities produced by human lung tumor cells associated with humoral hypercalcemia of malignancy. · 1989
- Reciprocal modulation of growth and liver functions of mature rat hepatocytes in primary culture by an extract of hepatic plasma membranes. · 1984
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese