Definition
US FDA substance register · UNII 2TXI2V75J2 · registered name MONOGUANIDINE PHOSPHATE · single chemical substance
Cosmetic roles
Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
GUANIDINE PHOSPHATEINCI구아니딘포스페이트Korean label name (MFDS standard)
- CAS No.chemical registry number
- 1763-07-1
- CAS No.chemical registry number
- 5423-22-3
- EC No.EU chemical inventory number
- 217-176-1
- EC No.EU chemical inventory number
- 226-551-9
- DTXSIDUS EPA chemical ID
- DTXSID201036309
- DTXCIDUS EPA compound ID
- DTXCID601367304
- IUPAC
- (Diaminomethylidene)ammonium dihydrogen phosphate
- Molecular formula
- CH8N3O4P
- Molecular weight
- 157.066 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 125.8 ℃
- Vapour pressure
- &, lt, 0.015 ㎩ (at 20 °C, OECD TG 104)
- Water solubility
- 0.95~1 g/100㎖ (at 25 °C, OECD TG 105)
- n-Octanol/water partition coefficient (Kow)
- &, lt, -3.48 ((OECD Guideline 107))
- Auto-ignition temperature
- &, gt, 400 ℃ ((EU Method A.16))
- Molecular weight
- 157.06
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
Classed as low1
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF), 2011, including the most recent partial revisions. according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to
Source: US EPA CompTox dashboard
Related literature
- Mitigation of environmental impact caused by flame retardant textile finishing chemicals · 2020
- Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium · 2019
- Prediction of the skin sensitization potential of polyhexamethylene guanidine phosphate, oligo(2-(2-ethoxy)ethoxyethyl) guanidinium chloride, triclosan, and mixtures of these compounds with the excipient propylene glycol through the local lymph node assay: BrdU-FCM · 2019
- Safety study, anti-inflammatory and antioxidant action of drug caramel with polyhexamethylene guanidine phosphate · 2016
- Humidifier disinfectant lung injury, how do we approach the issues? · 2016
Linked databases 12
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata