What is this ingredient?

미국 FDA 물질 등록 · UNII 5Z93L87A1R · 등록명 Guanine · 단일 화학물질

Is there safety information?

순도 높은 상태에서 안전하며, 일반적으로 피부 자극은 적습니다.

Are there usage precautions?

구아닌(CI 75170)은 주로 화장품에서 진주광택 효과를 내기 위해 사용됩니다. 주로 네일 제품, 아이섀도우, 립스틱 등에 사용되어 빛 반사로 인한 반짝임을 제공합니다.

All ingredients

Ingredient Dictionary

GUANINE

Guanine is a 2-aminopurine carrying a 6-oxo substituent.

Definition

US FDA substance register · UNII 5Z93L87A1R · registered name Guanine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Guanine is a 2-aminopurine carrying a 6-oxo substituent. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a member of 2-aminopurines, an oxopurine and a purine nucleobase. It derives from a hydride of a 9H-purine.

Source: PubChem

Guanine is a natural purine that conforms to the formula:

Cosmetic roles

Makes a clear formula opaqueOPACIFYINGAdds colourCOLORANT

Safety & regulatory references

Restricted: ASEAN · China · European Union · South Korea · Taiwan
Allowed colourant: ASEAN · Taiwan

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · Taiwan FDA cosmetic ingredients · US FDA color additives · US FDA prohibited and restricted ingredients

Argentina · Brazil

Field of application and/or use : Dye Substances allowed for all kinds of products.

United States

Eye Area : Yes
Generally (Includes Lipsticks) : Yes
External Use : Yes

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex IV (allowed colourants), entry 113

Source: EU allowed colourants (Annex IV)

Restriction IV/113

Source: EU CosIng ingredient list

Restriction IV/113 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name グアニン: 本品は、次の化学式で表される天然のプリン塩基である。

Source: JCIA labelling names (Japan)

Names & identifiers

GUANINEINCI구아닌Korean label name (MFDS standard)6H-Purin-6-one, 2-amino-1,9-dihydro-SynonymCI 75170SynonymグアニンJapanese labelling name

CAS No.chemical registry number: 73-40-5
EC No.EU chemical inventory number: 200-799-8
DTXSIDUS EPA chemical ID: DTXSID9052476
DTXCIDUS EPA compound ID: DTXCID6031049

IUPAC: 2-Amino-1,9-dihydro-6H-purin-6-one
Molecular formula: C5H5N5O
Molecular weight: 151.129 g/mol

Measured properties

Appearance: solid
Colour: white
Vapour pressure: 0.000000000096 ㎜Hg (@ 25 ℃, est.)
Water solubility: 2080 ㎎/ℓ (@ 37 ℃)
Vapour density: 5.22
Relative density: 1.67
n-Octanol/water partition coefficient (Kow): -0.91
Decomposition temperature: 360 ℃
Molecular weight: 151.13

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye7
Opacifer2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across