What is this ingredient?

미국 FDA 물질 등록 · UNII 6C0EL1931V · 등록명 HC BLUE NO. 2 · 단일 화학물질

All ingredients

Ingredient Dictionary

HC BLUE NO. 2

HC Blue No. 2 is a C-nitro compound.

Definition

US FDA substance register · UNII 6C0EL1931V · registered name HC BLUE NO. 2 · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

HC Blue No. 2 is a C-nitro compound.

Source: PubChem

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: South Korea
Restricted or banned: South Korea · Taiwan
Restricted: Taiwan · United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : Hair dye substance in nonoxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Maximum authorised concentration in the finished cosmetic product : 2.8%
Other limitations and requirements : • Do not use with nitrosating systems • Maximum nitrosamine content : 50 μg/kg • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use “wear suitable gloves” must be included in label or leaflet text
Conditions of use and warning which must be printed on the labels : Can cause allergic reaction Do not use to dye eyelashes or eyebrows

European Union

Product Type, body parts : Hair dye substance in non-oxidative hair dye products
Maximum concentration in ready for use preparation : 2.8%
Other : - Do not use nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers
Wording of conditions of use and warnings : Can cause allergic reaction

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 247 · maximum concentration 2.8% · applies to Hair dye substance in non-oxidative hair dye products

Source: EU restricted substances (Annex III)

Restriction III/247

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of HC Blue No. 2

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＨＣ青２: 本品は、次の化学式で表される頭髪用染料である。

Source: JCIA labelling names (Japan)

Names & identifiers

HC BLUE NO. 2INCI에치씨청색2호Korean label name (MFDS standard)Ethanol, 2,2'-[[4-[(2-hydroxethyl)amino]-3-nitrophenyl]imino]bis-SynonymＨＣ青２Japanese labelling name

CAS No.chemical registry number: 33229-34-4
EC No.EU chemical inventory number: 251-410-3
DTXSIDUS EPA chemical ID: DTXSID6020193
DTXCIDUS EPA compound ID: DTXCID80193

IUPAC: 2,2'-({4-[(2-Hydroxyethyl)amino]-3-nitrophenyl}azanediyl)di(ethan-1-ol)
Molecular formula: C12H19N3O5
Molecular weight: 285.3 g/mol

Measured properties

Appearance: Hc blue 2 is a dark blue to dark brown microcrystalline powder. (NTP, 1992) · Dark-blue (75% pure) or blackish-blue (98% pure) solid, with a copper cast, [HSDB]
Melting point: 182 to 194 °F (NTP, 1992) · 93-98 °C (98% pure)
Solubility: less than 1 mg/mL at 75 °F (NTP, 1992) · Soluble in water, ethanol, methanol and acetone

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as highly irritating1Classed as low2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

SkinSens1
Skin Sensitization · QSAR Predicted
Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: Commission Regulation (EC) No. 440/2008/EC, Method B.46; 'In-vitro skin irritation : Reconstructed human epidermis model test' according to
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Moderate or Mild Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD 437 : Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants (September 2009) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to