Ingredient Dictionary

HELIOTROPINE

Piperonal is an arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5.

How much products actually contain

No product states its amount yet.

Of the products containing it, 3 list it before the 1% line and 26 after it (usually 1% or less).

Products using this ingredient

12 of 29 confirmed · likeliest to carry enough first · See all 29

Definition

Piperonal is an arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum. It has a role as a fragrance, an insect repellent and a plant metabolite. It is an arenecarbaldehyde and a member of benzodioxoles.

Source: PubChem

US FDA substance register · UNII KE109YAK00 · registered name PIPERONAL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEGives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヘリオトロピン: 本品は、次の化学式で表される芳香族アルデヒド誘導体である。

Source: JCIA labelling names (Japan)

Names & identifiers

HELIOTROPINEINCI헬리오트로핀Korean label name (MFDS standard)1,3-Benzodioxole-5-carboxaldehydeSynonymヘリオトロピンJapanese labelling name

CAS No.chemical registry number: 120-57-0
EC No.EU chemical inventory number: 204-409-7
DTXSIDUS EPA chemical ID: DTXSID7025924
DTXCIDUS EPA compound ID: DTXCID505924

IUPAC: 2H-1,3-Benzodioxole-5-carbaldehyde
Molecular formula: C8H6O3
Molecular weight: 150.133 g/mol

Measured properties

Appearance: solid
Melting/freezing point: 36~37 ℃
Initial boiling point and range: 263~264 ℃
Flash point: &amp, lt, 110 ℃
Vapour pressure: 1 ㎜Hg(at 87.0 C)
Water solubility: &amp, lt, 0.2 %
Vapour density: 5.2 ()
n-Octanol/water partition coefficient (Kow): 1.05
Molecular weight: 150.13

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 208 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance201
Flavouring and nutrient3
Softener and conditioner2
Deodorizer2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as highly irritating1Classed as low3

The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: OECD Guideline 402 equivalent or similar to other guideline: IFF Protocol No. DLD (9/7/79) supplied by International Flavors & Fragrances, Inc. according to
Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) -Open cutaneous test
Ambiguous
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Ambiguous
eye irritation: in vivo · Screening · other guideline: the procedure originally suggested by Draize.,H.J. "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics", Assoc. of Food and Drug Officials of the U.S., Austin, Texas (1959). according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: protocol #RE(7/23/79) supplied by IFF, based on the procedure originally suggested by Draize.,H.J. "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics", Assoc. of Food and Drug Officials of the U.S., Austin, Texas (1959). according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to