Ingredient Dictionary

HEMA

2-hydroxyethyl methacrylate is an enoate ester that is the monomethacryloyl derivative of ethylene glycol.

How much products actually contain

No product states its amount yet.

Of the products containing it, 88 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

12 of 88 confirmed · likeliest to carry enough first · See all 88

Definition

2-hydroxyethyl methacrylate is an enoate ester that is the monomethacryloyl derivative of ethylene glycol. It has a role as an allergen and a polymerisation monomer. It is functionally related to a methacrylic acid and an ethylene glycol.

Source: PubChem

US FDA substance register · UNII 6E1I4IV47V · registered name 2-HYDROXYETHYL METHACRYLATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

HEMA is the organic compound that conforms to the formula:

Cosmetic roles

Builds artificial nailsNAIL SCULPTING

Safety & regulatory references

Restricted: United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : Nail Products
Other limitations and requirements : Professional use only
Conditions of use and warning which must be printed on the labels : • For professional use only • Can cause an allergic reaction

European Union

Product Type, body parts : Nail products
Other : Professional use only
Wording of conditions of use and warnings : For professional use only Can cause an allergic reaction

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 313 · applies to Nail products

Source: EU restricted substances (Annex III)

Restriction III/313 · SCCS opinion: OPINION ON the safety of cosmetic ingredients HEMA and Di-HEMA Trimethylhexyl Dicarbamate Submission I (Sensitisation only)

Source: EU CosIng ingredient list

Reviewed by CIR: Methacrylate Ester Monomers

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Methacrylate Ester Monomers Used in Nail Enhancement Products

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＨＥＭＡ: 本品は、次の化学式で表されるメタクリル酸２－ヒドロキシエチルである。

Source: JCIA labelling names (Japan)

Names & identifiers

HEMAINCI헤마Korean label name (MFDS standard)에이치이엠에이Korean label name (MFDS standard)2-Propenoic acid, 2-methyl-, 2-hydroxyethyl esterSynonym

CAS No.chemical registry number: 868-77-9
EC No.EU chemical inventory number: 212-782-2
DTXSIDUS EPA chemical ID: DTXSID7022128
DTXCIDUS EPA compound ID: DTXCID202128

IUPAC: 2-Hydroxyethyl 2-methylprop-2-enoate
Molecular formula: C6H10O3
Molecular weight: 130.143 g/mol

Measured properties

Appearance: liquid
Colour: colourless
Melting/freezing point: &amp, lt, -60 ℃
Initial boiling point and range: 250 ℃(calc.)
Flash point: 97 ℃(c.c.)
Flammability (solid, gas): combustible
Vapour pressure: 0.126 ㎜Hg (@ 25 ℃)
Water solubility: 100000 ㎎/ℓ (@ 25 ℃)
Vapour density: 4.5
Relative density: 1.034 (@ 25 ℃)
n-Octanol/water partition coefficient (Kow): 0.42
Auto-ignition temperature: 375 ℃ (@ 1024 hPa)
Viscosity: 6.63 cSt (@ 20 ℃)
Molecular weight: 130.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 14 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Monomers2
Film former2
Surface modifier2
Adhesion/cohesion promoter2
Intermediate2
Processing aids not otherwise specified1
Photosensitive agent1
Binder1

1 other uses

Thickening agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

13 skin studies and 6 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 19 studies

Skin Sens. 1
Skin Sensitization · Authoritative
Skin Irrit. 2
Skin Irritation · Authoritative
Skin sensitisation - category 1
Skin Sensitization · Screening
Skin irritation - category 2
Skin Irritation · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Magnusson and Kligman (1970)
Not classified
Skin Irritation · Screening
Sh
Skin Sensitization · Authoritative
Category 1
Skin Sensitization · Screening
Skin sensitization - Category 1
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Appraisal of the safety of chemicals in foods, drugs and cosmetics (1959) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Modified Buehler
Category 6.3B (Category 3)
Skin Irritation · Read Across
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Eye Irrit. 2
Eye Irritation · Authoritative
Eye irritation - category 2A
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2
Eye Irritation · Screening
Serious eye damage/eye irritation - Category 2B
Eye Irritation · Screening
Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: Appraisal of the safety of Chemicals in foods, drugs and cosmetics by staff of the Division of Pharmacology, FDA acc. to Draize according to