Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Definition
Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a member of 4'-methoxyflavanones, a monomethoxyflavanone, a trihydroxyflavanone and a member of 3'-hydroxyflavanones. It is a conjugate acid of a hesperetin(1-).
Source: PubChem
US FDA substance register · UNII Q9Q3D557F1 · registered name HESPERETIN · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 520-33-2
- EC No.EU chemical inventory number
- 208-290-2
- DTXSIDUS EPA chemical ID
- DTXSID4022319
- DTXCIDUS EPA compound ID
- DTXCID702319
- IUPAC
- (2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
- Molecular formula
- C16H14O6
- Molecular weight
- 302.282 g/mol
Measured properties
- Appearance
- Solid
- Melting point
- 227.5 °C
- Solubility
- 273 mg/L
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient2
- Softener and conditioner1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Hesperetin blocks poxvirus replication with a low tendency to select for drug‐resistant viral variants · 2024
- A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation · 2024
- Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice · 2024
- Healing Efficacy of Hesperetin-Containing Chitosan Gel in Burn Wound: Formulation Design and In Vivo Evaluation · 2022
- The Citrus Flavanone Hesperetin Induces Apoptosis in CTCL Cells via STAT3/Notch1/NFκB-Mediated Signaling Axis. · 2020
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese