Ingredient Dictionary

HEXAMIDINE

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.

Korean limit: 0.1%

HEXAMIDINE Molecular structure — Molecular structure

Definition

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It is functionally related to a hexane-1,6-diol.

Source: PubChem

US FDA substance register · UNII 3483C2H13H · registered name HEXAMIDINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Hexamidine is the organic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Restricted: China · South Korea
Allowed preservative: United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.1%

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.1%

Taiwan

Maximum concentration : 0.1%

European Union

Maximum concentration in ready for use preparation : 0.1%

Source: MFDS (Korea) cosmetic regulatory information

Restriction V/47

Source: EU CosIng ingredient list

Reviewed by CIR: Hexamidine and Hexamidine Diisethionate

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

HEXAMIDINEINCI헥사미딘Korean label name (MFDS standard)Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)bis-SynonymBENZENECARBOXIMIDAMIDE, 4,4'-(1,6-HEXANEDIYLBIS (OXY))BIS- AND ITS SALTS (INCLUDING ISETHIONATE AND P-HYDROXYBENZOATE)SynonymBENZENECARBOXIMIDAMIDE, 4,4'-(1,6-HEXANEDIYLBIS(OXY))BIS-, AND ITS SALTS (INCLUDING ISOTHIONATE AND P-HYDROXYBENZOATE)Synonym

CAS No.chemical registry number: 3811-75-4
DTXSIDUS EPA chemical ID: DTXSID60191524
DTXCIDUS EPA compound ID: DTXCID00114015

IUPAC: 4,4'-[Hexane-1,6-diylbis(oxy)]di(benzene-1-carboximidamide)
Molecular formula: C20H26N4O2
Molecular weight: 354.454 g/mol

Measured properties

Appearance: solid
Colour: white
Odour: odourless
Melting/freezing point: 246~247 ℃
Initial boiling point and range: 548.6 ℃(760mmHg)
Flash point: 120.4 ℃
Vapour pressure: 4.35E-12 ㎜Hg (25℃)
Vapour density: 12.23493268898861
Relative density: 1.19
n-Octanol/water partition coefficient (Kow): 4.873
Molecular weight: 354.446

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative1

Source: US EPA CompTox dashboard