What is this ingredient?

미국 FDA 물질 등록 · UNII 852A84Y8LS · 등록명 Hexetidine · 단일 화학물질

Ingredient Dictionary

HEXETIDINE

1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organic heteromonocyclic compound and an organonitrogen heterocyclic compound.

Korean limit: 0.1%

HEXETIDINE Molecular structure — Molecular structure

Definition

US FDA substance register · UNII 852A84Y8LS · registered name Hexetidine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organic heteromonocyclic compound and an organonitrogen heterocyclic compound.

Source: PubChem

Hexetidine is the heterocyclic organic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVECares for the mouthORAL CAREInhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Restricted: South Korea
Allowed preservative: United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.1%

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.1%

Taiwan · China

Maximum concentration : 0.1%

European Union

Maximum concentration in ready for use preparation : 0.1%

Source: MFDS (Korea) cosmetic regulatory information

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 19 · maximum concentration 0.1%

Source: EU allowed preservatives (Annex V)

Restriction V/19 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

HEXETIDINEINCI헥세티딘Korean label name (MFDS standard)5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-Synonym5-PYRIMIDINAMINE, 1,3-BIS (2-ETHYLHEXYL) HEXAHYDRO-5-METHYLSynonym

CAS No.chemical registry number: 141-94-6
EC No.EU chemical inventory number: 205-513-5
DTXSIDUS EPA chemical ID: DTXSID1045297
DTXCIDUS EPA compound ID: DTXCID9025297

IUPAC: 1,3-Bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine
Molecular formula: C21H45N3
Molecular weight: 339.612 g/mol

Measured properties

Appearance: Liquid · liquid
Boiling point: 160 °C at 0.4 mm Hg
Melting point: Freezing point = 70 °C
Solubility: Soluble in petroleum ether, methanol, benzene, acetone, ethanol, n-hexane, chloroform
Density: 0.8889 at 20 °C
Dissociation constant: pKa = 8.3
Melting/freezing point: 70 ℃
Initial boiling point and range: 160 ℃(0.4 mm Hg)
Flash point: 175 ℃
Vapour pressure: 1.54E-5 ㎜Hg (25°C)
Water solubility: 2.34 ㎎/ℓ (25℃)
Vapour density: 11.722471522264414
Relative density: 0.8889 (20℃)
n-Octanol/water partition coefficient (Kow): 5.26
Molecular weight: 339.6

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 8.3A (Category 1)
Eye Irritation · Read Across