Definition
US FDA substance register · UNII 538B2Q3HSV · registered name HEXYL METHACRYLATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Methacrylate Ester Monomers
Reviewed by CIR: Final Report on the Safety Assessment of Methacrylate Ester Monomers Used in Nail Enhancement Products
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 142-09-6
- EC No.EU chemical inventory number
- 205-521-9
- DTXSIDUS EPA chemical ID
- DTXSID4025406
- DTXCIDUS EPA compound ID
- DTXCID705406
- IUPAC
- Hexyl 2-methylprop-2-enoate
- Molecular formula
- C10H18O2
- Molecular weight
- 170.252 g/mol
Measured properties
- Appearance
- N-hexyl methacrylate is a clear colorless liquid. (NTP, 1992) · Clear colorless liquid, [CAMEO] Colorless liquid, [MSDSonline]
- Boiling point
- 153 to 185 °F at 8 mmHg (NTP, 1992) · 162 °C
- Solubility
- Slightly soluble (NTP, 1992) · Very soluble in acetone, benzene, ethyl ether, ethanol
- Density
- 0.88 (NTP, 1992) - Less dense than water, will float · 0.880 at 25 °C
- Colour
- colourless
- Initial boiling point and range
- 203 ℃(162℃(HSDB))
- Flash point
- 77 ℃(82℃(HSDB))
- Vapour density
- 5.9 ((AIR)=1)
- Relative density
- 0.880 (25℃)
- Molecular weight
- 170.25
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: according to Appraisal of the Safety of Chemicals in foods, drugs and cosmetics, FDA Draize (1959) according to - Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: see publication or details on study design
Source: US EPA CompTox dashboard
Related literature
- Formation of Superhydrophobic Coatings Based on Dispersion Compositions of Hexyl Methacrylate Copolymers with Glycidyl Methacrylate and Silica Nanoparticles · 2024
- Final Report of the Safety Assessment of Methacrylate Ester Monomers Used in Nail Enhancement Products1 · 2005
- Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products. · 2005
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata