What is this ingredient?

미국 FDA 물질 등록 · UNII 8F78EY72YL · 등록명 HEXYL SALICYLATE · 단일 화학물질

All ingredients

Ingredient Dictionary

HEXYL SALICYLATE

Hexyl salicylic acid is a benzoate ester.

How much products actually contain

No product states its amount yet.

Of the products containing it, 1 list it before the 1% line and 10 after it (usually 1% or less).

Products using this ingredient

11 of 11 confirmed · likeliest to carry enough first

Definition

US FDA substance register · UNII 8F78EY72YL · registered name HEXYL SALICYLATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Hexyl salicylic acid is a benzoate ester.

Source: PubChem

Hexyl Salicylate is the organic compound that conforms to the formula:

Cosmetic roles

Gives the product a scentPERFUMINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Restricted: European Union · International fragrance standard (IFRA) · United Kingdom

Source: EU Cosmetics Regulation · IFRA fragrance standards · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 380 · maximum concentration (a) 2 % (b) 0,5 % (c) 0,3 % (d) 0,001 % (e) 0,001 % (f) 0,1 % · applies to (a) Hydroalcoholic-based fragrances (except hydroalcoholic-based fragrances intended for children below 3 years of age) (b) All rinse-off products (except shower gel/bath products, hand wash, hair conditioner and shampoo intended for children below 3 years of age) (c) All leave-on products (except hair conditioner, body lotion, face cream, hand cream, lipstick/lip balm and fragrance products intended for children below 3 years of age) (d) Toothpaste (e) Mouthwash (f) Shower gel/bath products, hand wash, shampoo, hair conditioner, body, face and hand (skin) care products, lipstick/lip balm and fragrance products intended for children below 3 years of age

Source: EU restricted substances (Annex III)

Reviewed by CIR: Amended Safety Assessment of Salicylic Acid and Salicylates as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name サリチル酸ヘキシル: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

HEXYL SALICYLATEINCI헥실살리실레이트Korean label name (MFDS standard)Benzoic acid, 2-hydroxy-, hexyl esterSynonymサリチル酸ヘキシルJapanese labelling name

CAS No.chemical registry number: 6259-76-3
EC No.EU chemical inventory number: 228-408-6
DTXSIDUS EPA chemical ID: DTXSID4038924
DTXCIDUS EPA compound ID: DTXCID601473521

IUPAC: Hexyl 2-hydroxybenzoate
Molecular formula: C13H18O3
Molecular weight: 222.284 g/mol

Measured properties

Appearance: Liquid, Dry Powder, CBI · liquid
Melting/freezing point: 3.4 ℃
Initial boiling point and range: 290 ℃
Water solubility: 6.084 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 5.06
Molecular weight: 222.31

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 188 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance183
Deodorizer4
Flavouring and nutrient1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 2 eye studies are on record.

Classed as highly irritating2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Classification not possible
Skin Irritation · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 6.3A (Category 2)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
SkinIrr2
Skin Irritation · QSAR Predicted
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Classification not possible
Eye Irritation · Screening