Are there usage precautions?

주로 건조한 피부에 수분 공급 피부 장벽을 강화하여 보호하는 역할 (추천 피부타입: 민감성 제외 모든 피부 타입)

Ingredient Dictionary

HEXYLENE GLYCOL

2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).

How much products actually contain

No product states its amount yet.

Of the products containing it, 491 list it before the 1% line and 864 after it (usually 1% or less).

Products using this ingredient

12 of 1,355 confirmed · likeliest to carry enough first · See all 1,355

Definition

2-methylpentane-2,4-diol is a glycol in which the two hydroxy groups are at positions 2 and 4 of 2-methylpentane (isopentane).

Source: PubChem

US FDA substance register · UNII KEH0A3F75J · registered name HEXYLENE GLYCOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENTKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGMixes and holds oil and water togetherSURFACTANT - EMULSIFYINGGives the product a scentPERFUMINGSurfactant that lifts dirtSURFACTANT - CLEANSING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヘキシレングリコール: 本品は、次の化学式で表される二価アルコールである。

Source: JCIA labelling names (Japan)

Names & identifiers

HEXYLENE GLYCOLINCI헥실렌글라이콜Korean label name (MFDS standard)2,4-Pentanediol, 2-methyl-SynonymヘキシレングリコールJapanese labelling name

CAS No.chemical registry number: 107-41-5
EC No.EU chemical inventory number: 203-489-0
DTXSIDUS EPA chemical ID: DTXSID5021885
DTXCIDUS EPA compound ID: DTXCID101885

IUPAC: 2-Methylpentane-2,4-diol
Molecular formula: C6H14O2
Molecular weight: 118.176 g/mol

Measured properties

Appearance: Hexylene glycol is an oily colorless liquid with a mild sweet odor. Floats and mixes slowly with water. (USCG, 1999) · CBI, Liquid, Other Solid
Odour: Mild sweetish · ATMOSPHERES ESSENTIALLY SATURATED AT ROOM TEMP ARE DETECTABLE BY ODOR...
Boiling point: 387 °F at 760 mmHg (USCG, 1999) · 198 °C at 760 mm Hg
Melting point: -58 °F (USCG, 1999) · Freezing point = -50 °C (glass or vitreous condition)
Solubility: Miscible (NIOSH, 2024) · Miscible with water
Density: 0.923 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.923 g/cu cm at 15 °C
Stability: Stable under recommended storage conditions.
Colour: colourless
Melting/freezing point: -50 ℃
Initial boiling point and range: 198 ℃(760 mm Hg)
Flash point: 96 ℃
Evaporation rate: 0.003
Upper/lower flammability or explosive limits: 8.1 / 1.2 %
Vapour pressure: 0.07 ㎜Hg (25℃)
Water solubility: 100 g/100㎖
Vapour density: 4.1
Relative density: 0.923 (15℃)
n-Octanol/water partition coefficient (Kow): 0.58
Auto-ignition temperature: 306 ℃
Decomposition temperature: 3.4356x10+9 (J/kmol)
Viscosity: 34 (20℃)
Molecular weight: 118.174

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 85 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solubility enhancer45
Solvent14
Surfactant (surface active agent)6
Fragrance5
Emulsifier2
Viscosity modifier2
Softener and conditioner2
Filler1

8 other uses

Binder1
Dye1
Flavouring and nutrient1
Anti-adhesive/cohesive1
Wetting agent (non-aqueous)1
Processing aids not otherwise specified1
Chelating agent1
Plasticizer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 5 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 12 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Skin Irrit. 2
Skin Irritation · Authoritative
Not classified
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: Journal officiel de la Republique Francais du 29/1/1980. Arrete du 18/12/79 relatif a la Methode Officielle pour l'appreciation de l'agressivite superficielle cutanee par applications iteratives pendant 6 semaines d'un produit cosmetique ou d'hygiene corp according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Category 2A
Eye Irritation · Screening