Definition
US FDA substance register · UNII 7P0O8282NR · registered name ETHYLENE GLYCOL MONOHEXYL ETHER · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 112-25-4
- EC No.EU chemical inventory number
- 203-951-1
- DTXSIDUS EPA chemical ID
- DTXSID1026908
- DTXCIDUS EPA compound ID
- DTXCID606908
- IUPAC
- 2-(Hexyloxy)ethan-1-ol
- Molecular formula
- C8H18O2
- Molecular weight
- 146.23 g/mol
Measured properties
- Appearance
- Liquid · Colorless hygroscopic liquid, [CHEMINFO]
- Boiling point
- 208 °C @ 760 MM HG · 208.3 °C
- Melting point
- -45.1 °C · -45 °C
- Solubility
- SLIGHTLY SOL IN WATER, VERY SOL IN ALC & ETHER · Solubility in water: poor
- Density
- 0.8894 @ 20 °C/20 °C · Relative density (water = 1): 0.89
- Melting/freezing point
- -50.1~-45 ℃
- Initial boiling point and range
- 208~209 ℃ (760mmHg)
- Evaporation rate
- 0.82
- Upper/lower flammability or explosive limits
- 8.1 / 1.2 %
- Vapour pressure
- 0.155 ㎜Hg (25℃)
- Water solubility
- 0.99 g/100㎖ (20℃)
- Vapour density
- 5.04
- Relative density
- 0.8878-0.8894
- n-Octanol/water partition coefficient (Kow)
- 1.86
- Auto-ignition temperature
- 220 ℃
- Molecular weight
- 146.23
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 55 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Cleaning agent19
- Solubility enhancer12
- Surfactant (surface active agent)10
- Solvent9
- Processing aids not otherwise specified2
- Impregnation agent1
- Film former1
- Chemical reaction regulator1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Corrosive
skin irritation: in vivo · Screening · other guideline: DOT Appendix A HMR HM-215A 173.1300 IATA Resolution 618, Attachment A, 3.8.2 according to - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 2
Skin Irritation · Screening - Corrosive
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion) equivalent or similar to - Classification not possible
Skin Sensitization · Screening - Skin Corr. 1B
Skin Irritation · Authoritative - Category 2B
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese