Beta-thujaplicin is a monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4.
Definition
Beta-thujaplicin is a monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities. It has a role as an antibacterial agent, an antineoplastic agent, an antifungal agent, an antiplasmodial drug and a plant metabolite. It is a monoterpenoid, an enol and a cyclic ketone. It derives from a hydride of a cyclohepta-1,3,5-triene.
Source: PubChem
US FDA substance register · UNII U5335D6EBI · registered name .BETA.-THUJAPLICIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.10 g
- Maximum amount per 100 g (Cosmetics that may be used for mucosa) : 0.050 g
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヒノキチオール: 本品は、次の化学式で表される環式アルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 38094-79-0
- CAS No.chemical registry number
- 499-44-5
- EC No.EU chemical inventory number
- 207-880-7
- DTXSIDUS EPA chemical ID
- DTXSID6043911
- DTXCIDUS EPA compound ID
- DTXCID4023911
- IUPAC
- 2-Hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
- Molecular formula
- C10H12O2
- Molecular weight
- 164.204 g/mol
Measured properties
- Appearance
- Solid · solid
- Boiling point
- 140.00 °C. @ 10.00 mm Hg
- Melting point
- 52 - 52.5 °C
- Solubility
- 1.2 mg/mL at 25 °C
- Melting/freezing point
- 51.5 ℃
- Initial boiling point and range
- 303.71 ℃
- Vapour pressure
- 0.000039 ㎜Hg
- Water solubility
- 1200 ㎎/ℓ
- Relative density
- 1.0606
- n-Octanol/water partition coefficient (Kow)
- 1.83
- Molecular weight
- 164.201
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 7 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Fragrance2
- Anti-static agent2
Source: US EPA CompTox dashboard
Related literature
- Cocrystallization-Mediated Property Enhancement of Hinokitiol · 2026
- Interactions of hinokitiol with fungal membrane lipids in model systems. · 2025
- Hinokitiol as a modulator of TLR4 signaling and apoptotic pathways in atopic dermatitis. · 2023
- Hinokitiol Selectively Enhances the Antibacterial Activity of Tetracyclines against Staphylococcus aureus · 2023
- Synergistic Anticancer Effects of Curcumin and Hinokitiol on Gefitinib Resistant Non-Small Cell Lung Cancer Cells · 2018
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese