Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.
Definition
Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.
Source: PubChem
US FDA substance register · UNII 3X7931PO74 · registered name Hydrocortisone Acetate · single chemical substance
Cosmetic roles
Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction II/300 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
HYDROCORTISONE ACETATEINCI하이드로코르티손아세테이트Korean label name (MFDS standard)Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11.beta.)-Synonym
- CAS No.chemical registry number
- 50-03-3
- EC No.EU chemical inventory number
- 200-004-4
- DTXSIDUS EPA chemical ID
- DTXSID0048686
- DTXCIDUS EPA compound ID
- DTXCID0028612
- IUPAC
- (8xi,9xi,14xi)-11beta,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
- Molecular formula
- C23H32O6
- Molecular weight
- 404.503 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Comparative in Vitro Evaluation of Hydrocortisone Acetate Permeation Through Porcine Skin and Synthetic Membranes Using Franz Diffusion Cells · 2026
- Innovative Hydrocortisone Acetate and Pramoxine Hydrochloride Topical Cream Formulations for Anorectal Conditions: Enhanced In Vitro Release Profile · 2025
- Novel stability indicating UHPLC method development and validation for simultaneous quantification of hydrocortisone acetate, pramoxine hydrochloride, potassium sorbate and sorbic acid in topical cream formulation · 2020
- Comparison of efficacy and safety between Tacrolimus and Hydrocortisone acetate in 2-5 years old children with atopic dermatitis · 2015
- [Liberation of hydrocortisone acetate from different commercial formulations]. · 2004
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English