Definition
US FDA substance register · UNII DH9E53K1Y8 · registered name Norflurane · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 811-97-2
- EC No.EU chemical inventory number
- 212-377-0
- DTXSIDUS EPA chemical ID
- DTXSID1021324
- DTXCIDUS EPA compound ID
- DTXCID901324
- IUPAC
- 1,1,1,2-Tetrafluoroethane
- Molecular formula
- C2H2F4
- Molecular weight
- 102.032 g/mol
Measured properties
- Appearance
- 1,1,1,2-tetrafluoroethane appears as a colorless gas with a slight ethereal odor. Vapors are heavier than air. Shipped liquefied under own vapor pressure. Flash point 351 °F. Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen. · Liquid, CBI, Gas Vapor
- Odour
- Faint ethereal odor
- Boiling point
- -26.5 °C at 1 atmosphere · -26 °C
- Melting point
- -103.296 °C · -101 °C
- Solubility
- Insoluble in water · Soluble in ethyl ether
- Density
- 1.2072 g/cu cm at 25 °C · Critical density: 0.508 g/cu cm
- Stability
- Stable under recommended storage conditions.
- Viscosity
- 0.204 cP at 25 °C · 205 cP (25 ℃)
- Colour
- colourless
- Melting/freezing point
- -101 ℃
- Initial boiling point and range
- -26 ℃
- Vapour pressure
- 4990 ㎜Hg (25 ℃)
- Water solubility
- 2040 ㎎/ℓ (25 ℃)
- Vapour density
- 3.5
- Relative density
- 1.2072 (25 ℃)
- n-Octanol/water partition coefficient (Kow)
- 1.06
- Auto-ignition temperature
- (&, gt, 750℃)
- Molecular weight
- 102.03
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 25 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Propellants, non-motive (blowing agents)15
- Foamant6
- Refrigerants4
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 2 eye studies are on record.
The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Not classified
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: The protocol published by "Arrete" of 1 February 1982 in the "Journal Officiel de la Republique Francaise" of 21 February 1982. according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: the protocol of Guillot-Gonnet-Clement-Brulos published by the AFNOR: FD n T03-300, 1982 - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: The protocols published by Arrete of 21 September 1984, in the "Journal Officiel de la Republique Francaise" of 24 October 1984 and 9 February 1985. according to - Not classified
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese